2/
First and foremost, let’s be clear that to be dead by brain criteria, the patient must have cessation of ALL brain function *INCLUDING absence of respiratory drive.*
Thinking "But... I thought you just said...."?
3/
The contradiction here lies in that ventilators are sometimes too sensitive.
4/ An example:
Patient suffered a significant, radiographically evident brain injury & had no evidence of other brainstem reflexes. Confounders r/o: no substances (>5 1/2lives of all sedation / paralytics), paCO2 35, T 36.5, and metabolic parameters wnl.
Vent RR set at 14.
5/
BUT.
Ventilator shows RR27
The trigger is a "flow trigger" of 1.0 L/min.
6/
1.0L/min is a very sensitive flow trigger. A change in gas flow of 1L/min triggers the inspiratory valve to open and deliver a breath to the patient.
7/ In brain death, the pt is often in a hyperdynamic cardiovascular state.
Hyperdynamic precordium ➡️
Displacement of intrathoracic volume ➡️
Oscillations that cause movement of gas greater than the trigger sensitivity.
Giving you “breath” in absence of respiratory drive.
8/ Here the flow trigger is set to 6 L/min and the RR to 8. The patient breaths @ RR 8.
9/ What if 6 L/min isn’t sensitive enough and the patient just can’t generate that flow? Is it unfair? Too high a bar?
@capt_ammonia (who taught me everything I know about this) would advise trying a pressure trigger.
10/ Pressure triggers require the patient generate a sufficient reduction in airway pressure to trigger the ventilator.
Here I switched the patient into a pressure triggered SBT and no respiratory drive was observed.
11/ But what if that’s just not sensitive enough??
Fair question. That is what the apnea test is for!
This is NEVER a replacement for apnea testing, just a screen to see if the patient is appropriate for formalized testing.
12/ So, if you think the patient otherwise meets criteria for brain death testing, but the RR doesn't match what you set, please call us to help troubleshoot!
13/ Getting brain death testing right is one of the single most important things we do and is not only important in giving families closure, but saving lives through organ donation, if pursued.
2/ Reminder: The 12 cranial nerve nuclei are located in the brainstem, and if you have trouble remembering where they are, welcome to the club. Here’s a reminder! Will post the medulla section Monday, stay tuned.
3/ We’ll move from central to peripheral etiologies.
The brainstem is like Times Square in NYC- so much going on in a very small space.
A small insult can easily cause damage to multiple cranial nerves. amiright, #stroketwitter?