Few places in the world have suffered more losses from COVID than New York.

4 factors for disconnect below in cases and deaths:

-Health system not overwhelmed
-Better treatments
-More testing = milder cases detected
-Some are mild reinfections in people who already had COVID
One reason why I think immunity is playing a role is that the reduction in deaths with second wave seems to depend on how high the first wave was.
It's a complicated argument, but my summary after looking at this is that undiagnosed reinfections probably exist quite a bit more than we initially thought but they do not have the natural history of COVID for the first time: Much milder due to better prepared immune system.
This has some implications for how vaccine effect will play out. Once most people have been vaccinated, an increasing proportion of new infections will likely be in the vaccinated, and I think the clinical course will be like the flu or common cold; deaths will be very low.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Vincent Rajkumar

Vincent Rajkumar Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @VincentRK

3 Apr
From Feb 1, the date COVID vaccine effect probably started: Israel provides a preview into what can happen in the US as we race to get 80% of eligible public vaccinated.

Deaths and hospitalizations eventually will be driven by cases in unvaccinated adults.
Deaths in the US have resumed their downward trend after a brief plateau. I hope this continues. Metrics of vaccine success to track will be hospitalizations, ICU admissions, and deaths.
I'm saying 80% of the eligible public as target for herd immunity as opposed to 80% of the whole country because while we are not vaccinating kids, we also do have at least 10% of the population who have had confirmed COVID and at least another 10% who have had undiagnosed COVID.
Read 4 tweets
1 Apr
How long will protection from COVID vaccines last?

If you are going by lab studies & antibody levels: Few months

If you are going based what we know about the immune system, and in terms of ability to prevent serious disease & deaths: Years or decades.

That's my opinion FWIW.
The big unknown is the ability of the virus to mutate to a variant that is both more infectious and more lethal while being different enough to evade vaccine generated immune response.

The reason I'm not alarmed by this prospect is the natural redundancy of the immune response.
Of course no one can know for sure, only time will tell. Whatever you hear is one persons opinion versus the other. No more, no less.

Again I'm using metrics of ability to prevent serious disease and deaths. Not any infection.
Read 5 tweets
31 Mar
Europe is struggling with the vaccine roll out. Any decision on vaccines needs to take into account that every single day 2500 lives are being lost due to COVID. That's the risk/benefit trade off to consider.

The UK in comparison is doing extremely well with vaccinations. ImageImage
Deaths are driven by people getting COVID. People get COVID from other people.

The elderly get COVID not just from other elderly people but also from young people. High COVID rates in young people places the lives of elderly at greater risk.
Vaccination rates. Image
Read 4 tweets
30 Mar
Why do you often get confusing and contradictory messages from experts?

Why does medical expert opinion sometimes seem incorrect, outdated, or even contrary to the evidence?

1/ Medicine is really complicated. No one is truly an expert except in a tiny segment of it, at best.
2/ When a car doesn't work a good mechanic knows what each part does. To know what's wrong. Doesn't need a randomized trial to know how to fix it.

Our body is not like a car. We don't know a fraction of how it works and what each part does. Human biology is still in its infancy
3/ Medicine moves at speed of light. Keeping up to date is no small task. Even if you read all the latest information as they come in, you may have time to scan the headlines or abstract—
Not critically review it.
Read 12 tweets
29 Mar
There may be a 4th wave in COVID cases, but I don't think there will be another significant wave in deaths. Ripple maybe. Not a wave.

We are doing very well in vaccinations. The vaccines work. There is reason to be optimistic.
I'd rather that deaths not be at the level of 1000 per day. It's really high and I would like to seen it come down drastically.

I'm confident if we keep vaccinating the way we have been, this will happen. Sooner rather than later.
All of the cases I have heard of in fully vaccinated people have been mild or asymptomatic.
Read 7 tweets
29 Mar
When we say "Vaccine Passport" some people may have negative reactions. I'd rather call it proof of vaccination.

The reality is that air travel and big gatherings in most places are likely to require proof of vaccination or a negative test. Of the two, I'd go with the vaccine.
Remember, your own friends and family may have small gatherings, and without being explicit they may only invite people who they know are vaccinated. Just for your own safety and theirs.

I strongly believe vaccines are they way to get us to normal, and soon.
As someone lucky to have been vaccinated, I can tell you the peace of mind is incredible.
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!