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Mac n’ Chise 🧬🦠🧫

@sailorrooscout

5 Apr

We know individuals who recover from SARS-CoV-2 infections develop effective T-cell immunity. A new study in Nature finds individuals are able to gain T-cell memory in the absence of a detectable infection simply from exposure!
nature.com/articles/s4146…

Here researchers reported virus-specific CD4+ and CD8+ T-cell memory in recovered COVID-19 patients and close contacts. Data showed that the memory CD4+ and CD8+ T cells of 94.44% and 83.33%, respectively, of the COVID-19 patients successfully underwent expansion.

Their results indicated that most of the recovered COVID-19 patients had developed effective T-cell memory pools against SARS-CoV-2 and their close contacts to a lesser degree. The proliferation capacity, size and quality of T-cell responses in close contacts were also readily

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Mac n’ Chise 🧬🦠🧫

@sailorrooscout

2 Apr

According to the CDC, those who are fully vaccinated can travel “at low risk to themselves,” both within the United States and internationally, but they must continue to take precautions like wearing a mask in public, avoiding crowds, maintaining social distancing.

Vaccinated individuals do not need to get a coronavirus test before arriving in another country, unless required to do so by authorities at the destination, and they do not need to quarantine after returning to the United States unless required to do so by local jurisdictions.

Vaccinated travelers should have a negative result from a coronavirus test before boarding a flight back to the United States, and they should get tested against three to five days after their return home. The recommendations do not alter the guidelines for the unvaccinated.

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Mac n’ Chise 🧬🦠🧫

@sailorrooscout

1 Apr

Fantastic news out of Pfizer this morning!

•91.3% vaccine efficacy observed against COVID-19, measured seven days through up to six months after the second dose

•100% effective in preventing COVID-19 cases in South Africa, where the B.1.351 lineage is prevalent!

Pfizer’s vaccine was 100% effective in preventing severe disease as defined by the U.S. Centers for Disease Control and Prevention and 95.3% effective in preventing severe disease as defined by the U.S. Food and Drug Administration. This is AMAZING.
pfizer.com/news/press-rel…

This does NOT mean the vaccine is only effective for 6 months. It means that at the 6 month mark this level of high protection is still present! Vaccine safety now evaluated in more than 44,000 participants 16 years of age and older, with more than 12,000 vaccinated participants

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Mac n’ Chise 🧬🦠🧫

@sailorrooscout

30 Mar

This is fantastic. Research out of Israel shows there have NOT been ANY vaccine-resistant SARS-CoV-2 variants found in the population. Comparing the prevalence of differing variants in the vaccinated and unvaccinated population, no difference was detected.
ynetnews.com/health_science…

Remember, vaccines are preventives, not cures! Some people will get infected despite being vaccinated or recovered as no vaccine is 100% effective (but remember it will protect you from the worst of it all). Researchers observed if these individuals were disproportionately being

infected by a vaccine-resistant variant. They were not! Indeed there are variants, and E484K variants in the population. While still in the early days of their vaccination program, the variants do not appear to be gaining any advantage which means the vaccines are stopping them!

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Mac n’ Chise 🧬🦠🧫

@sailorrooscout

28 Mar

Vaccines are preventives, not cures. Immunity is not instantaneous. It is important to realize that vaccinated people who do get infected tend to only have mild or even asymptomatic cases of COVID-19, and don’t require hospitalization. This means the vaccines are indeed working.

With this said, when we see cases rising, or cases of reinfection, especially in places that have had a very robust vaccination program, we have to realize there is a period of time (~14 days after your 2nd dose) where you are considered “fully vaccinated.” It doesn’t just happen

with the snap of a finger. This is why it is still important for you to wear your mask after getting vaccinated. Masks and social distancing will not be forever, believe me, but this is not the time to let up. It is important for you to know there is an end in sight.

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Mac n’ Chise 🧬🦠🧫

@sailorrooscout

28 Mar

•Antibodies from infected and vaccinated individuals bind to the B.1.351 RBD
•Convalescent sera through eight months can neutralize the B.1.351 variant
•Serum from vaccinated individuals retain neutralization against the B.1.351 variant
cell.com/cell-host-micr…

Researchers compared antibody binding and live virus neutralization of sera from individuals naturally infected and Moderna vaccinated individuals against two SARS-CoV-2 variants: B.1 containing the spike mutation D614G and variant B.1.351 containing additional spike mutations

and deletions. Researchers found that sera from acutely-infected and convalescent COVID-19 patients exhibited a 3-fold reduction in binding antibody titers to variant B.1.351’s receptor binding domain of the spike protein and a 3.5-fold reduction in neutralizing antibody titers

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