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19 Apr, 7 tweets, 1 min read
Q: How many people have died globally from COVID-19?

A: Probably more than the confirmed count, but it's really hard to say

coronavirus.medium.com/how-many-peopl…
The basic idea here is that we could be either undercounting or overcounting COVID-19 deaths

I think the most likely explanation is some combination of the two
Based on some very careful examinations of death reporting systems, we can say that there are probably some portion of deaths that are recorded as due to COVID-19 but were not caused by the virus
However this is likely to be pretty modest in scale - mostly impacts high-income countries, and inflates the death toll by maximum 10-15%
Conversely, there is strong evidence that in low-income places, the death toll from COVID-19 is undercounted, sometimes by a factor of 10x or more
Even in high-income places, there is evidence from excess mortality calculations that some proportion of deaths caused by COVID-19 are being missed
All in all, we may be overcounting COVID-19 deaths by a modest amount, but we are almost certainly undercounting them by a much larger fraction. The true death toll may be 50%+ higher

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More from @GidMK

20 Apr
"Chronic disease has caused COVID-19 deaths, if we didn't have so much diabetes fewer people would've died" - incredibly dumb argument for many reasons, not least that it is true of LITERALLY ALL HUMAN DEATHS
Yes, if we had solved the biggest medical issue of the modern age fewer people would've died of COVID-19

What of it?
I mean, seriously, we've been trying to 'fix' NCDs for decades, and while they are in theory somewhat preventable they are still a large and growing problem in most places in the world
Read 4 tweets
19 Apr
Omg I am LOVING this story

TL:DR - it is not a study, published in a journal dedicated to unusual hypotheses, and not really "from a major university" 1/n
2/n The article in question is a review of face masks. At face value, it's essentially an opinion piece arguing that masks are ineffective ncbi.nlm.nih.gov/pmc/articles/P…
3/n Digging a little bit deeper, some of the stuff in here is pretty obviously wrong. For example, this incorrect statement about 99% mild/asymptomatic is referenced to Worldometers (not a specific graph, just the site)
Read 15 tweets
19 Apr
This is an absolutely terrifying article

"there is a shortage of everything — oxygen, drugs, beds, vaccines, even cremation space"

hindustantimes.com/opinion/indias…
Many places in India had very large initial epidemics, and it has been proposed that some cities (i.e. Mumbai) might have been at or near herd immunity towards the end of last year
The new massive waves even in areas with many infections before raise several possibilities, none of them great

1. reinfections
2. variants
3. large over-ascertainment of past infection
Read 8 tweets
16 Apr
Interesting point - 0.008% is, all things being equal, a LOWER rate of infections in vaccinated people than I'd expect
In the US, the exact incidence of COVID-19 infections per week is hard to estimate, but it's probably been about 10% of the whole country infected since January (roughly), for a weekly incidence of ~0.5%
The vaccines used in the US are 80-95% effective, and about 100 million people have been vaccinated in that time period
Read 5 tweets
11 Apr
Fascinating study demonstrating the issues with selection bias in seroprevalence estimates

Using a selected sample of participants, the estimated prevalence of past COVID-19 infection doubled (!) nature.com/articles/s4146…
The study is really interesting. They used an existing representative sample of people aged >30 to estimate the population prevalence of antibodies to SARS-CoV-2
They then added a second group. These were people who had not previously signed up to the existing cohort, but were eligible
Read 9 tweets
11 Apr
An update on this whole bizarre experience - the journal has now published a "typeset" version of the paper, which has deleted the lengthy personal attack

There are quite a number of issues remaining, but this at least is good
The author has now included a slightly odd statement in the appendices. It's worth remembering that the original appendix contained a number of factually inaccurate statements about myself and co-authors
I would also suggest that hurting people's feelings is a bizarrely patronizing thing to say. Defamation of PhD students in published scientific work is about more than "feelings"
Read 7 tweets

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