[1/n] "Oxygen" - If you know anyone in India - it's one word you hear over & over. It's a critical life saving supply. In context of COVID surge in India, we are sharing open source design for "pulse dose" O2 conservation device - potential to save 50% O2. Not medical device yet.
[2/n] The idea "pulse dose system" is simple. When you exhale, you don't take in O2 while the tank still delivers. For mild COVID19 patients on nasal cannula - this O2 is wasted. A simple pressure based detection & an electronic valve can release O2 only during inhalation.
[3/n] The implementation above is simple - and not a medical device. A lot of work still needs to be done and tested clinically. We are releasing the design/implementation in open source - to engage manufacturing partners in an emergency. docs.google.com/document/d/1gN…
[4/n] This is work with an incredible trio in my lab - @hongquan_li @deepak_me90 @lietk12 who have dedicated every waking minute of last year on critical care and ventilation issues. This is a natural extension of our pez-globo.org effort with @FluidDanamics KaiKuck
[5/n] As you know; the devil of implementation is in details. Medical grade valves are out of stock. For 1 year - we developed a new valve design that can be rapidly manufactured with @BharatForgeLtd - this valve provides a safe interface (no grease etc) for patients.
[6/n] As we rapidly build a response to emergency situation in India - we have started @IndiaCOVIDSOS - and have built a frugal engineering team. For this project, we need medical device electronics experts, regulatory experts, manufacturing partner and financial support.
[7/n] In the next 24hrs, we will be releasing open source designs for multiple oxygen conservation devices. It's been an incredible partnership at @IndiaCOVIDSOS with clinician behind @OpenCritCareOrg Just like last year, we will document our work on - docs.google.com/document/d/1gN…
[8/n] Help us to deliver solutions to folks gasping for air because of supply shortages & distribution issues - but ALSO build equitable world & opensource implementation of life saving medical solutions with local partners throughout the world. We are exhausted - could use help.
[9/n] We can come out of this crisis - but need to work together. If you are looking to help in the medical crisis in India - consider joining @IndiaCOVIDSOS - look for needs and try solving them. This pandemic has taught us how to work together. So let's fight.

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More from @PrakashLab

5 Sep 20
(1/n)Excited to announce new course I have been planning for 5 years BioE271: Frugal Science frugalscience.org structured as global participatory class open to all. 50% Stanford students 50% global participant. Learn how to solve serious challenges with little bit of play
(2/n)Together we will explore principles of frugal science to design scalable solutions with cost/performance rubric. With examples we will look at imp of fundamental science of everyday building blocks. We will juggle rigors of applied math/physics with creativity of a toy maker
(3/n) Global Participatory Community Health Track:
Can we diagnose deadly infectious diseases under a tree? Environmental Planetary-Health Activists Track: Can we build tools to make measurements at planetary scale.
Read 10 tweets
20 Jul 20
(1/n) Excited to share #Pufferfish an open-source full-feature mechanical ventilator reference design capable of volume & pressure control with assist modes, both invasive/non-invasive ventilation & features necessary to support COVID19 patients pez-globo.org
(2/n) Pufferfish is a result of a large scale intl collaborative effort - Pez-Globo - between my lab @Stanford, @brownengin @FluidDanamics & @UofU_Anesthesia @kkuck - clinicians, engineers, scientists, industrial/manufacturing partners @BharatForgeLtd @Waymo @BlackrockMicro
(3/n) Heart of whole operation are students, postdocs, clinicians, innovators & volunteers - working with tenacity, precision & passion I have never witnessed before - too many to name individually (list pez-globo.org/core-team) - spreading across US, India, Nepal and Kenya
Read 18 tweets
3 Jul 20
(1/n) Excited to share Handyfuge-LAMP; a low-cost & electricity-free centrifugation for isothermal SARS-CoV-2 detection in saliva. With COVID19 cases increasing globally, diagnostics needs to be accessible to everyone - including resource limited regions medrxiv.org/content/10.110…
(2/n)This simple electricity-free LAMP protocol builds on fantastic work by Cepko lab at Harvard [medrxiv.org/content/10.110…], but with ahand powered centrifuge to make this assay completely electricity free for resource constrained settings. All you need is everything in this pic.
(3/n) If you would like to try it, here is the visual summary of every step of the way; with centrifugation steps linked below.
Read 10 tweets
7 May 20
(1/n) Thrilled to share latest pre-print from lab - open imaging tool we have been working for the last 3 years "PlanktonScope V1 & 2" - modular (100x cost reduction) platform to enable citizens/sailors to study the world's largest habitat - our oceans! biorxiv.org/content/10.110…
(2/n) Before describing the science/vision and the back story of 'Planktonscope" - it's important to highlight the incredible trio in lab that made this dream come true - led by Thibaut Polina @chevreuil3000, Adam Larson @planktonico & @hongquan_li - merging of art/design/science
(3/n) What is the problem we are trying to solve? The ocean is a big place (360 million sq km) - and presence/absence & type of microscopic life in ocean holds secrets to well being of our planet. Not enough research vessels/scientists/$ to map this microscopic life in its glory
Read 15 tweets
29 Apr 20
(1/n) What does cotton-candy machine, van de graaff generator & COVID19 have in common? Here we present a possible solution for distributed, small scale manufacturing of N95 material for communities that can not source pre-approved masks. Pre print: arxiv.org/abs/2004.13494
(2/n) Disclaimer: If you have access to an authentic N95 mask, that is the best possible solution. But majority of parts around the world, N95 supplies have never existed. How can we boot-strap and support small scale manufacturing capacity for this critical supply locally?
(3/n) Our journey began a month ago when we had first shared results on use of cotton-candy machine to spin polypropylene fibers:
Only possible because of incredible students Anton Molina, @Pranavvyas94 @nikitakhlystov and co-authors.
Read 12 tweets
25 Mar 20
In COVID19 crisis, health care workers globally need upward of 80M+ N95 grade masks. N95 masks are fibrous nano-materials made via melt-blown; large scale factory can only make 1M mask/day. What if another solution existed to this problem - Introducing Project 1000x1000 (1/n)
Introducing Project 1000x1000: These are not normal times; we need new solutions. What if (big IF) 1000's of small businesses/fablab's could make specialized nano-materials for roughly 1000 to 10K N95 grade mask/day locally. 1000x1000 is a million mask/day produced locally. (2/n)
What if the only thing you needed was a few Dremel and a waste material: Styrofoam. This is an idea inspired by a cotton candy machine - if you take a polymer solution and spin it really fast (rotary jet spinning), you get a nano fiber mesh suitable to make filters.
Read 12 tweets

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