According to "aspiring physician" Edward Nirenberg, "The collective conclusion from our understanding of these biological process is that a naked mRNA in the cytosol has no potential to end up in a cellular compartment that contains our own DNA . . ."

edwardnirenberg.medium.com/no-really-mrna…
Not entirely convincing, but it's a start.
"If you already have mitochondrial and metabolic dysfunction, then you may, as a result, have a poor first line of defense against COVID-19. Future work should consider mitochondrial biology as a primary intervention target for SARS-CoV-2 and other coronaviruses . . ."
The virus may attack mitochondria, and doctors are aware the mitochondria are at play in order to recover . . .
I have yet to find definitive information one way or another regarding mRNA vaccines, gene therapy dynamics and mtDNA (mitochondrial DNA), but the little evidence I could find is pointing in the direction of "no immediately discernable, long-term negative side effects."

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