Viral dose is an important factor in severity of COVID. As India waits for vaccines, I urge people in India to wear masks and avoid crowds. This is the best way to reduce viral dose, and repeated exposures.

Lower viral dose will reduce severity of illness. And reduce deaths.
For over a year we have been saying that masks play a role in reducing viral dose, and at this point I'm more convinced than ever before. Have to unearth old tweets and graphics.
Severity of COVID is influenced by many factors, but unfortunately most of these are not in our control. Not easily "changeable": age, obesity, comorbidities, type of mutant variant, genetics, etc.

The one factor that is in our control is reducing viral dose at exposure.
As with any poison, dose matters. Do everything you can to reduce dose by staying away from crowds/social distancing, and wearing a mask.…
One person who was onto this from the start was @DrSidMukherjee
From a year ago👇…
And @MonicaGandhi9 and Dr. Rutherford wrote about it as well in @NEJM…
Finally I wish I knew who posted this epic graphic we saw early on in the pandemic last year, and one I had retweeted many times but cannot find the source.

You get less wet if both of you are wearing pants.
Get vaccinated as soon as it's available. It's the best way to protect yourself. Avoid crowds & wear some type of well fitting mask that covers your nose & mouth well. It will reduce your chance of infection, reduce severity of COVID if u do get infected, & reduce spread.

• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with Vincent Rajkumar

Vincent Rajkumar Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @VincentRK

27 Apr
US Vaccine Progress: Over 50% of the eligible population (140 million out of ~265 million) have had at least 1 dose of COVID vaccine.

Herd Immunity (80%):
125 million to go with vaccine alone.
Only 70 million more to go if we also include people who have had COVID & recovered
Two assumptions: I'm assuming ~30% of children & adults have had COVID & recovered (30 million confirmed; 60 million unconfirmed).

Also assuming all people who got need 2nd dose to be fully vaccinated will eventually get it (recognizing this is not happening & we need to fix it)
I'd prefer 125 million more people as the minimum target for vaccination. But suspect cases will decrease quite a bit if we get 70 million more vaccinated.

The last 50 million will be hard. We will need to overcome vaccine hesitancy through people they trust.
Read 6 tweets
27 Apr
As COVID rips through India, the nearly 100,000 doctors of Indian origin who are in the US feel both helpless & determined to help at the same time.

Most of us have close family in India. Every few hours we get calls about some friend or relative who's very ill with COVID.
The scale of the pandemic is hard to describe in words. This figure is a serious underestimate.
We are grateful that the US will send vaccines, vaccine raw materials, test kits, emergency supplies, and more. India needs all the help it can get.
Read 6 tweets
24 Apr
This is a plea to the US government to help India. What you can do:

-Help with Oxygen & Oxygen generators
-Release Astra Zeneca vaccine supplies
-Lift the export ban & send them raw materials for vaccines

As bad as this looks. It's 10 times worse. The Indian people need you.
This is not only the right thing to do. It is also wise. If this absolutely stunning and dramatic spike is due to a bad COVID variant, then it is going to affect us.

It will be self defeating to crush COVID only to let a bad COVID variant get us again.

Please act urgently.
It is not everyday that a request like this goes out. On April 16 new cases were 180,000 per day.

It is a week since this request. It is now 300,000 new cases per day. Urgent will be an understatement. @adarpoonawalla
Read 6 tweets
24 Apr
Studies were reporting 40-50% seroprevalence in big cities in India even by December. The same cities (eg. Delhi, Mumbai, Chennai) are now totally overwhelmed with COVID.

What does this mean? How could this even happen?…

@SmritiMallapaty @nature
First, sampling in big cities could have been wrong and didn't estimate the true seroprevalence accurately even within each city, let alone India.
Second, even if 50% seroprevalence was true, that still leaves 50%.

50% of India still means 650 million people susceptible. Twice the size of the US population.
Read 7 tweets
23 Apr
Updated Risk of vaccine related cerebral venous sinus (or splanchnic vein) thrombosis associated with low platelets

Astra Zeneca
1 in 100,000 (EU)
1 in 250,000 (UK)

1 in 500,000 overall.
1 in 150,000 for women age 18-49.

No risk seen with Moderna or Pfizer vaccines.
The risks are extremely low. Awaiting CDC panel recommendations on J&J pause.
The pause was justified. To determine the numerator & the denominator. CDC panel has voted today to resume vaccinations with the J&J vaccine.…
Read 6 tweets
22 Apr
One year had gone by. We thought that given India's population and crowding, that the number and severity of COVID was inexplicably low.

Well that part was true. But not because of a miracle or massive undercounting. It was sadly because the worst was yet to come. A crisis.
Either lockdowns and restrictions had worked really well, and once everything broke free after November, COVID did what it does.


New dangerous mutants evolved.


Both happened together.

End Result: The present crisis.

In this time of crisis & desperation, 2 problems must be dealt with simultaneously.

1) Care of patients with COVID in a sensible way that optimizes the use of scarce resources & minimizes loss of life

2) Reduce new cases by masking, distancing, & rapid vaccination
Read 7 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!