A country that has prevailed vs B.1.1.7
Those states that were in trouble?
No longer the case. In descent or flat.
Overall cases are down 30%, hospitalizations and deaths down ~10% over the past 2 weeks
Here's the lineage (variant) map of the US through the pandemic, based on 360,000 sequences. Dark blue is B.1.1.7 that became dominant throughout. The only other major variant competing now is P.1 (Brazil) at 2% prevalence outbreak.info/location-repor…
By getting nearly 150 million Americans vaccinated, the US averted pronounced surges, the worst seen in many countries, such as the UK and Israel, and throughout most of Europe
Instead, we just had a B.1.1.7 bump.
Had Americans not come together to get all the vaccinations done, including many days getting shots for well over 1% of the whole population, this would not have been the case.
But we've still got work to do. With >50,000 new cases a day we are nowhere near containment like the UK and Israel. That 5-15X gap is associated with a 10-15% more population vaccinated. If we can get that done, summer will be a time to celebrate.
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If you're interested in how AI grew up over the past 15 years, and where it's headed, this new book tells the story in a riveting, page-turner way. In the new Ground Truths with @scmallaby
In 2010, when @GoogleDeepMind was formed, well before deep learning was taking hold, @demishassabis predicted AGI by 2030 and called out the use of agents
@GoogleDeepMind @demishassabis This is pretty striking
(please excuse typo, DeepMind's)
Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts 1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below
2. Engaging in > 1 type of physical activity was generally correlated with better outcomes compared with 1 type (T1,2,3)
People age 70+ should not be taking aspirin at any dose for prevention. Results of randomized trials show higher risk of all-cause mortality, major bleeding events and deaths from cancer. p 153, SUPER AGERS book
President Trump takes 325 mg aspirin/day. The randomized trials tested 75-81 mg/day. His doctors recommended low-dose aspirin for heart event prevention. That recommendation is ill-founded based upon best evidence in older individuals. nejm.org/doi/full/10.10… academic.oup.com/eurheartj/arti…
As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role nature.com/articles/s4358…
The new special issue @ScienceMagazine features Immunity with 4 outstanding review papers, 5★
Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses science.org/toc/science/cu…
We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And that leads to a unified model to pull it all together. (open-access)
I review 4 new reports, summarized here: 1. The proteins from senescent cells predict age-related clinical outcomes 2. A new epigenetic age clock connects the dots between aging, the immune system, inflammation and lifestyle factors 3. People with a fast pace of aging had an increased risk of cognitive impairment, age-related diseases, disability, and mortality 4. The Importance of “Immune Resilience” for Healthspan
And present a unified I/I model for what we now know