Samir Gupta Profile picture
May 4, 2021 9 tweets 2 min read Read on X
1/Re. NACI’s recent communications. No one is saying to hide info from the public. What people are concerned about is the way that info is being conveyed (and to some extent, its accuracy). IMO, here is how they should have framed this:
2/First: all vaccines are extremely effective. All of them, including the AZ vaccine, will prevent severe disease and death in close to 100% of people. This is NOT about effectiveness.
3/Second: if you got your AZ vaccine over a month ago, you are golden – you will not get this clotting complication and you should have ZERO REGRETS!
4/The AZ vaccine, and to a lesser extent, the J&J vaccine are associated with an extremely low risk of an unusual type of clotting complication. In most cases, we can catch that complication and treat it completely.
5/Because COVID is so active in most parts of the country, the risk of catching the virus, and even the risk of dying of COVID are much higher than the risk of this complication. So for the vast majority of people, the benefits of vaccination far outweigh the risk.
6/In fact, this complication is so rare that the average Canadian’s chances of dying in a car accident over 1 yr are about 10x higher than having this complication, and the average Canadian’s chances of dying of COVID since the start of the pandemic have been about 100x higher.
7/There are always exceptions. If you live in a low risk neighbourhood, and/or are at extremely low risk (e.g. you never leave your house), it may be reasonable to wait for an mRNA vaccine, which doesn’t have this type of complication.
8/If you think your risk of contracting COVID is really low, here is a tool to help you to compare that risk with the risk of a vaccine complication: insert infographic decision aid comparing COVID vs VITT risk by: age, comorbidities, basic risk behaviours, community incidence.
9/If you are the National Advisory Committee on Immunization, then surely you can muster the resources to accompany your advice for “informed consent” with a tool that will enable that otherwise very complex informed consent process in the real world. It’s on you.

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More from @SammyG_MD

May 13, 2021
1/ Small Gupta family case series. Now 31 relatives + 4 friends with COVID in India. 32/35 took steroids. All were normoxic when given steroids (3 later deteriorated and actually needed them).
2/ Typical outpatient starting dose is medrol 32mg/day or equivalent. All of them get a taper, total duration 14-18 days. (If actually hypoxemic and hospitalized, doses are much higher - in the medrol 80 bid range. And durations even longer).
3/ CRP, IL-6 being measured every few days in outpatients and steroids titrated accordingly. Remember - these people all have saturations >95%.
Read 6 tweets
May 12, 2021
1/People keep asking what they can “do” now that they’re vaccinated (half of adults in Canada!). Can we follow the @CDCgov advice here in Canada too? What evidence can we use to guide us?
2/The @CDCgov has said that fully vaccinated people can attend small outdoor gatherings and even outdoor dinners without a mask, including with people who are unvaccinated.
3/The @CDCgov advice makes a lot of sense because vaccinated people are less likely to get sick – i.e. the risk of symptomatic infection for vaccinated people is much lower. And risk of severe disease is almost nil.
Read 12 tweets
Oct 6, 2020
1/Lots of discussions about #lockdown vs no lockdown in medicine, politics, around dinner tables, just about everywhere. @fordnation says he needs more evidence. I just reviewed the topic for a debate @accpchest. So I'll oblige. theglobeandmail.com/canada/article…
2/I'll start by stating the obvious: lockdowns work. This was shown in multiple Spanish Flu pandemic studies, including this one demonstrating reduced excess flu mortality with earlier, more aggressive lockdown, comparing 43 US cities: pubmed.ncbi.nlm.nih.gov/17684187/
3/100 years later, evidence holds. COVID-19 lockdowns reduce transmission, hospitalizations/ICU, deaths. Shown in modelling, pre/post, interrupted time series, contemporaneous group predictor studies, across continents, countries. Excellent meta-analysis: bmj.com/content/370/bm…
Read 13 tweets

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