Talk #2 from Plenary III is from @NUFeinbergDerm, José-Marc Techner, presenting "Oral Vitamin D3 reduces chemical-induced skin inflammation in humans" #SID2021 1/n
The focus of this work is to understand the mechanisms of chemical-induced skin inflammation, and to unravel how systemic vitamin D3 can suppress the deep dermal inflammatory response. @SID2021 2/n
The investigators designed a double blinded RCT - 28 healthy volunteers had 2 exposures to topical nitrogen mustard, half got vitamin D3 and half got placebo at the 2nd nitrogen mustard exposure, and labs, skin biopsy, and skin redness was measured throughout 3/n #sid2021
The 2nd application was to the contralateral arm, and this study has multiple comparisons that can give insight into inflammation including skin injury after chemical application, intervention with vitD3, resolution of skin injury, and residual changes after healing 4/n #sid2021
RNAseq and proteomic analysis was applied to compare responses between the vitD3 and placebo groups. This analysis suggest that inflammatory markers were reduced at the RNA and protein level in patients receiving vitD3. #sid2021 5/n
But the most striking result? Completely healed lesions (6 weeks after application of nitrogen mustard) had RNA and protein signatures of inflammation that were dramatically different between groups, with no upregulation of inflammatory markers in vitD3 group #sid2021 6/n
This work is just the beginning - taking a ratio of vitamin D metabolites may be a way of predicting sustained vs non-sustained responders, and multi-dosing regimens may help optimize the immunotherapeutic response to vitD3 therapy #sid2021 7/7
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