CELLS in Hemat 💪🏻

Sickle cell=Drepanocyte➡️SCD
Tear drop=Dacrocyte➡️MF
Spur cell=Acanthocyte➡️Liver ds
Burr cell=Echinocyte➡️Uremia/PK def
Target cell=Codocyte➡️Hb'pathies
Bite cell=eccentrocyte➡️G6PD def
Pencil cell=ovalocyte➡️IDA
Pincered cell➡️Band 3 def
Prickle cell➡️PK def
Sickle cells, not hard to identify.
Can't miss these isn't it ?
Tear drop cells a/w marrow fibrosis.
Acanthocyte/spur cells , irregularly spaced "spikes" !!
A/w liver disease, abetalipoproteinemia.
In contrast to the above image, note how the "spikes" are regularly spaced !!
These are ecchinocytes/burr cells a/w uremia.
Bull's eye. Hard to miss these target cells. Seen in thalassemia and other Hb'pathies and also with asplenia.
That took a BIG "bite" out of that !!!
G6Pd deficiency.
All images are from the @ASH_hematology image bank. A big thank you for existing 💪🏻🙏🏻

P.S. I am not a hemato-pathologist. Those guys are from a different planet. RESPECT 🙏🏻

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More from @nihardesai7

Apr 4
Hey #MedStudentTwitter 👋🏼

Do you know what this image shows?

Obviously you do !!

If not, read this short thread 👇🏻

#MedTwitter

1/6 Image
Yeah, those are hemighost cells !

That's a hallmark of severe oxidative damage to red cells. Most often seen in G6PD deficient individuals!

I say most often because it can happen in patients with normal G6PD levels when the oxidative damage is severe 😭

#MedTwitter
2/6
You cannot see Heinz bodies in that image 😔 They will NOT be seen on Romanowsky stains !!!

The red cell will appear like an emptied out "ghost cell" when the hemoglobin denatures 😔 That's what you saw ☝🏼

👇🏻 Is a supravital stain showing Heinz bodies (blue dots)!

#MedTwitter Image
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Feb 28
An easy way to remember serum protein electrophoresis for #MedstudentTwitter !

In myeloma, the thumb goes ⤴️ and the pinky finger goes ⤵️

To know more than this, follow along 👇🏼

#MedTwitter

1/16 Image
Now let's see what each spike represents!

α1 =α1 antitrypsin +others (small amount)

α1 antitrypsin (AT) is an ACUTE PHASE REACTANT, so it'll ⤴️in INFLAMMATION

Obviously, α1 is⤵️in α1 AT deficiency!

It's quite simple, isn't it?

Wait, why is α2 ⤴️ in acute inflammation🤔

2/16
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To answer that, we need to know what α2 contains !

Since it's elevated in acute inflammation, it must be an inflammatory marker 🤷🏻‍♂️

Yes, it is 🙌🏻

α2 contains ceruloplasmin, haptoglobin and α2 macroglobulin, all acute phase reactants!

Now we know why we get 👇🏼 pattern !

3/16 Image
Read 16 tweets
Aug 16, 2023
📢📢 𝐍𝐄𝐖 𝐓𝐇𝐑𝐄𝐀𝐃 🧵

This is for everyone who uses 𝙘𝙮𝙘𝙡𝙤𝙨𝙥𝙤𝙧𝙞𝙣𝙚, so I'm guessing a lot of people would read this short thread !

It's every transplanter's friend; kidney/🫀/ liver/ BMT 💪

Follow along to learn more 👇

1/20

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Let's roll back time 🔙 to the 1960's 😍

@thebeatles, @pinkfloyd and @ledzeppelin were ruling the charts🤘

Those were good days as far as music was concerned 🎶

Not so good for transplants!

There weren't many immunosuppressive drugs available back then😭

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2/20
Transplanter docs were using AZATHIOPRINE & CORTICOSTEROIDS to suppress the immune system 😳😮

These drugs weren't good enough 😭

•Azathioprine - cytopenia
•Steroids - Don't get me started !
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#MedTwitter

The transplanter docs wanted 👇🏻
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Jun 2, 2023
Hey #medicine residents !!

Time to talk about EOSINOPHILS today. Not as common a consult as thrombocytopenia and anemia but important nonetheless.

A short 🧵 to touch upon all things eosinophilia 👇🏻

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Before we go any further, it's important to know this

🩸Eosinophil ≥ 500 is ABNORMAL

Eosinophil is a predominantly tissue dwelling cell so 🩸 eosinophil DON'T correlate with tissue damage 🤷‍♂️

We see a few patients with ⤴️⤴️Eos and no 🫀🫁 injury !!
Where do eosinophils come from?

Short answer: Bone Marrow

They are cells of the granulocytic lineage, siblings of neutrophils and basophils, children of the myeloblast (image👇🏻)

IL5 is the cytokine responsible for it's production, important to know because we have anti IL5 mAb Image
Read 24 tweets
May 25, 2023
A thread of some of my #MedEd threads !!

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This one's about my approach to a consult for thrombocytopenia 👇🏻



#MedTwitter
Go through this before you see a consult sent by the ObGyn 😂🤷‍♂️



#MedTwitter
Read 15 tweets
May 22, 2023
Hey #medicine residents !!

PLEASE TRANSFUSE BLOOD PRODUCTS JUDICIOUSLY 🙏🏻

Not every patient with anemia needs blood and not is blood transfusion free of complications.

I'll list out a few TRANSFUSION REACTIONS in case you'll have forgotten about them 👇🏻

#MedTwitter

1/10
Let's start w/ TACO🌮

This isn't the good Mexican 🌮 we love🤣

This is pulmonary oedema resulting from overzealous transfusion🤷‍♂️

Risk factors: patients who can't handle fluids we'll, i.e. patients w/ kidney,heart disease etc

Totally avoidable complication🙏🏻

#MedTwitter

2/10 ImageImage
A close differential of TACO is TRALI. The symptoms are the same but this is non-cardiogenic pulmonary oedema.

So BNP will be normal here, neck veins won't be dilated

TACO needs diuretics and some restraint on your part🤣

TRALI=supportive care

#MedTwitter

3/10
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