Has the largest genome of any known human virus [200 genes]
Most humans harbour latent CMV, infection aquired in childhood.
Site of latency in humans-❓
In murine models- hepatic sinusoidal cells.
May 16, 2021 • 10 tweets • 7 min read
Want to know why #Mucormycosis is more common post #COVID19 and not so common after leukemia's or other illnesses treated with steroids ?
Read on !!
These are the major reasons in my opinion:
1. The NUMBER of #COVID19 pts is far GREATER than the number of leukemia pts we treat in a year. Thus a lot more people are getting steroids at this point in time and thus a lot more are at risk of steroid related complications.
May 15, 2021 • 6 tweets • 3 min read
So there are a lot of people asking about the risk factors for #mucor post #covid.
The biggest risk factor isn't the steroid itself, it's the hyperglycemia that it causes. If the sugars are well controlled using insulin the risk is almost negligible. So STOP freaking out !!
The 2nd major risk factor is prolonged NEUTROPENIA but that's a problem in our #Hematology patient population and not in #covid patients, so we can safely ignore that for now.
#FERRITIN is being widely ordered these days. Let's dive into the details and learn more about this protein. A short thread for those interested. Covers some history, biology and practical aspects about FERRITIN.
It was discovered in 1937 by Laufbérger but it wasn't until 1972 that an assay was devised to measure serum ferritin.
Ferritin is present in 2 forms
👉 Intra-cellular (in the cytosol)
May 4, 2021 • 8 tweets • 5 min read
So mucor is on the rise, time for a quick revision. A short thread for those interested.
It's a bad infection with an unreasonably high mortality(40-80%) which depends on the organ involved.
Risk factors: DM/ neutropenia/ HSCT
Mucormycosis is caused by fungi of order "MUCORALES" which includes rhizopus/mucor/licthemia/cunninghemela species. But DON'T WORRY species identification doesn't change treatment so we don't need to get to that.
May 1, 2021 • 9 tweets • 5 min read
Got #covid ? Don't worry it's not a death sentence.
Step 1: Isolate and monitor
I assume u must have started isolating even before you tested + , if not, do so immediately. Get the others at home tested ASAP. Monitor your temperature and oxygen saturation.
Step 2: Managing Co-morbidities
If u have any co-morbidity continue to take the meds you were already on. Don't STOP meds for ur diabetes or hypertension or thyroid d/o.