Recommended gap between 2 doses of #covishield increased to 12 to 16 weeks.
π A look at the trial data behind this and practice followed by other countries.
β Key finding from AstraZeneca (Covishield) studies that showed an efficacy of 76% for 90 days after single dose.
1/5
π A look at the trial data behind this and practice followed by other countries.
β Key finding from AstraZeneca (Covishield) studies that showed an efficacy of 76% for 90 days after single dose.
1/5
β
No significant reduction in protection seen from days 22 to 90 after a single dose - implying that even a single dose can offer significant protection for upto 3 months.
β In this case, it was only prudent to spread out the doses so that more could get atleast 1 dose.
2/5
β In this case, it was only prudent to spread out the doses so that more could get atleast 1 dose.
2/5
β
Additional data that showed increased efficacy (for symptomatic cases) when the gap between 2 doses was > 12 weeks. Efficacy of 81% noted with a > 12 week interval.
β These 2 factors have lead most countries administering Covishield to recommend a gap of 8 to 12 weeks.
3/5
β These 2 factors have lead most countries administering Covishield to recommend a gap of 8 to 12 weeks.
3/5
β
Spain and Canada are 2 countries that are following a 16 week interval as suggested in India now.
β With a 3 to 4 month gap, ensuring that people don't miss their second dose will be a challenge that should be effectively addressed.
4/5
β With a 3 to 4 month gap, ensuring that people don't miss their second dose will be a challenge that should be effectively addressed.
4/5
πLink to relevant paper: thelancet.com/journals/lanceβ¦
Note: The delayed dosage was not by design, but caused due to issues and delays in the AstraZeneca trials.
5/5
Note: The delayed dosage was not by design, but caused due to issues and delays in the AstraZeneca trials.
5/5
What happens if you do not take the second dose at all?
Partial, shorter term protection.
While there is efficacy brought in by the first dose, a second dose of a 2 dose vaccine is required to BOOST efficacy and provide extended protection.
Ensure that you get both doses.
Partial, shorter term protection.
While there is efficacy brought in by the first dose, a second dose of a 2 dose vaccine is required to BOOST efficacy and provide extended protection.
Ensure that you get both doses.
β’ β’ β’
Missing some Tweet in this thread? You can try to
force a refresh
γ
