behind the main fleet but sliding like a SSN under the water is India's first mRNA vaccine candidate HGCO19 by Gennova, Pune helped by the dept of biotech . With enrollment starting for phase1/2 trials a month ago, maybe by 1Q CY22 we will see EUA.
thehindubusinessline.com/news/national/…
their chart showing the lipid carrying the mrna inside the muscle to the cells ... creation of spike proteins to train the immune system ...
one tieup with HDT Bio seattle, who seem like have lipid and mrna tech expertise hdt.bio/technology
gennova.bio/mrna-vaccines/ "technology platform will empower India handle COVID-19 pandemic but also preparedness for any future pandemic or endemic stage that will follow (mutation in the virus, unvaccinated low-risk population, newborns, etc.)utilizing its rapid development path"
very strategic project imo under DBT given that mRNA is another of these high tech machans denied to us sdre nations. its ability to rapidly scale and target new uses vs traditional approaches meant mRNA vaccines were first to enter human trials and first to gain EUA
people who know the ins and outs of the microfluid injector tech to safely wrap the mrna in protective lipid mix for getting the finished product is alleged to be in "low 100s" worldwide..same as the hot section of gas turbines. will be good to get a initial grip on this thing.

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More from @daeroplate_v2

14 May
New barrons guide thread for post covid world 😺. Add any I missed useful for cocktail party namedropping

BSL3
BSL4
Epidemology
Spike protein
Protease
Host cell
Pandemic
R number
lockdown1/2/3/4
Unlock1/2/3/4
Zoom
Teams
Homework upload
Spike protein
Essestial service pass
Horseshoe bat
Yunnan
Wuhan instt of virology
Bat lady scientist
Lab escape
Patient 0
Triage
Intubate
Gavi
Covax
HCQ
Invermectin
Wet market
Zoonotic
Adenovirus
Inactivated virus
Attenuated virus
mRNA
moderna
Biontech
Gamelaya/rdif
Bharat biotech
Haffkine instt
Serum instt
Poonawalla
Ella
Hrct
D-dimer
Ground glass look in lung xray
ACE2 receptor
Lancet
Phase1/2/3
Efficacy
Rtpcr
RAT
nose swab
Antibody test
Ventilator
O2 concentrator
Bipap machine
N95
kn95
Ffp1/2
Fabiflu
Remdesivir
Read 7 tweets
23 Apr
We will spend all day today debating and booing merkel but real soln is to fix things for autonomy ... few of the outragers will want to spent cycles on even thinking what are the gaps. and there r yawning gaps if we have to airlift o2 machines from germany now.
Victory begins with a honest self assessment and then course corrections in a continuous cycle. There are 1000s of unsexy but essential gear with not even indian license prod let alone IP.
If we can supply 1000s of type of machinery to world markets with indian IP (like germany does) would not hear such rude comments. But then giving gyaan on ai/ml/5th gen and salivating over FANG is our elite youths fascination 😂💁
Read 4 tweets
17 Apr
India is going to need a centrally funded and run FEMA type agency to maintain strategic stockpiles of everything needed in a world where borders are harder , travel is dying and global supply chains iffy, plus state govts a mixed bag. NDRF is not it as its disaster relief... 1/5
Desi FEMA will need people from various manufacturing, IT, operations research, supply chain, finance , pure science and logistics .. maybe as a bigger adjunct to the proposed tri service joint logistics command 2/5
Needless to say ias cannot run the show in this. PM having to chair meetings on oxygen supply yesterday shows how things allowed to drift,lack of initiative at normal level. A few superstars/sage-kings cannot do, need process in all things to reduce the modi/napolean need 3/5
Read 5 tweets
14 Apr
Did some casual searching based on items mentioned as subject to shortages and export embargoes overt n covert here livemint.com/companies/news…
The first is single use bioreactor bags. The leading makers per a video that explains their use are Image
Second is beta propiolactone - imported from germany . Used to inactivate viruses so covaxin needs it en.wikipedia.org/wiki/Beta-Prop…
Read 8 tweets
4 Apr
Sorry to sound like a revered “youthful” leader but fighting naxals is far beyond simplistic drone/iaf/sf approaches being demanded and is more “structural” 🙄1/n
If there is no legitimate economic activity like in old nagaland, like nscn the naxals will live on extortion from civil officials and forest timber/poaching/mining stealing plus foreign donations and benami investments 2/n
If there is new economic acitivity like new roads and railways, naxals will feed on this too via extortion and ogw workers fronting local businesses 3/n
Read 9 tweets
6 Mar
Article in greek media about jf17. I have used yandex translator. Goog translate failed on the long text. Fascinating insights in operarional exp of jf17
Pakistan specifically envisioned acquiring a fighter jet, comparable to the Su-30MKI, Mig-29 and Mirage-2000. China even said it would import the aircraft because of its superior capabilities. However, the aircraft is far from its designed capabilities,
as it is a low-cost fighter developed with low-quality Chinese avionics and weapons.
Read 35 tweets

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