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P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
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14 May, 6 tweets, 2 min read
Blood clotting and long, healthy life.

A loss-of-function mutation in the gene that encodes for PAI-1 is associated with lower fasting insulin, and...

7 years longer lifespan - huge.

Thread 👇

advances.sciencemag.org/content/3/11/e…
PAI-1 is plasminogen activator inhibitor, and increased levels mean less fibrinolysis, and a tendency for blood to remain clotted.

Increased PAI-1 is associated with obesity, particularly visceral fat.

nature.com/articles/nm079…
Patients with peripheral arterial disease have higher PAI-1, and exercise training significantly reduces it.

sciencedirect.com/science/articl…
Drug targeting of PAI-1 inhibits metabolic dysfunction and atherosclerosis.

pubmed.ncbi.nlm.nih.gov/32268785/
PAI-1 and the inhibition of breakdown of blood clots appears to be a major factor in atherosclerosis and is inversely related to insulin levels and long life.

It has nothing to do with cholesterol, and everything to do with insulin - and of course, blood clotting.
Metformin Prevents Alcohol-Induced Liver Injury in the Mouse: Critical Role of PAI-1

Since metformin decreases glucose and insulin, and extends lifespan, all of this again implicates PAI-1 and blood clotting.

sciencedirect.com/science/articl…

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More from @Mangan150

P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
3 May
Do you want to lose 15, 20, or even 30 pounds in the next 90 days?

And keep it off forever?

I’ve got something for you

You see, there’s a lot of advice out there about getting lean

A lot of it "works", per se

The problem is...
Almost every “hack” or strategy you hear about is either

*complicated and time consuming, and so not designed for your real life

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P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
1 May
Iron depletion by phlebotomy (bloodletting) improves insulin sensitivity in patients with fatty liver.
gastrojournal.org/article/S0016-…
Why does that matter? Iron consumption in U.S. diets has increased by ~50% since 1979.

The largest source of iron is grains, because flour is enriched with iron.

fns-prod.azureedge.net/sites/default/…
Metformin may improve insulin sensitivity in part through reduction in body iron stores. eje.bioscientifica.com/view/journals/…
Read 4 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
30 Apr
A few years ago my mother had a stroke and was in ICU. After discharge she went to a convalescent hospital for a few weeks.

The food there was appalling. Sugar and cheap carbs everywhere. Imagine oatmeal with maple syrup and a glass of OJ for breakfast.
So I requested a meeting with the lead dietitian. I told her that I wanted my mother to get bacon and eggs for breakfast, and none of that sugary stuff. Meat or eggs at every meal.

She looked at me like I was from Mars, but ultimately she complied.
Meanwhile, twice a day I brought my mother a whey protein drink I devised, giving her an extra 30-50 g/d protein, plus some NAC and magnesium and creatine.

My mother is still alive today at 99, and probably would not be if she continued eating hospital style.
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P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
30 Apr
Use of metformin and acarbose is associated with reduced risk of death from Covid-19.

No one using both meds before admission died.

Metformin lowers blood glucose, and acarbose blocks dietary glucose absorption.

Could you get same risk reduction by not eating carbs?
No association with insulin or other meds.

assets.researchsquare.com/files/rs-28730…
Metformin Associated with Decreased Covid Mortality Among Nursing Home Residents

*Relative to those not receiving diabetes medications, residents taking metformin had about half the death rate

Diabetics on metformin at lower risk than non-diabetics sciencedirect.com/science/articl…
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P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
26 Apr
Elite athletes have disturbed glucose control.

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers
sciencedirect.com/science/articl…
5 hours a week of vigorous exercise is the safe upper limit for long-term health and life expectancy.

mayoclinicproceedings.org/article/S0025-…
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P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
26 Apr
Cholesterol, whether in your diet or made by your body, does not cause heart disease.

Yet the idea that it does is the central dogma of modern medicine.

Many things follow from this.
Like dietary guidelines that advise you to avoid meat and eat lots of carbs.

Like widespread prescription of statins. That's like the one thing all doctors want to do: put you on a statin.
When the real causes of coronary heart disease can be traced to the crap food made from sugar, white flour, and seed oils.

Throw in lack of exercise.

In other words, diabesity.
Read 4 tweets

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