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P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
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26 Apr, 5 tweets, 2 min read
Elite athletes have disturbed glucose control.

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers
sciencedirect.com/science/articl…
5 hours a week of vigorous exercise is the safe upper limit for long-term health and life expectancy.

mayoclinicproceedings.org/article/S0025-…
Associations of jogging with mortality. Optimal associations were surprisingly low at slow pace, 2 to 3 times a week, from 1 to 2.4 hours total.
sciencedirect.com/science/articl…

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More from @Mangan150

P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
26 Apr
Cholesterol, whether in your diet or made by your body, does not cause heart disease.

Yet the idea that it does is the central dogma of modern medicine.

Many things follow from this.
Like dietary guidelines that advise you to avoid meat and eat lots of carbs.

Like widespread prescription of statins. That's like the one thing all doctors want to do: put you on a statin.
When the real causes of coronary heart disease can be traced to the crap food made from sugar, white flour, and seed oils.

Throw in lack of exercise.

In other words, diabesity.
Read 4 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
23 Apr
Calorie restriction (CR) has long been known to extend lifespan and healthspan in animals.

But the benefits of CR may be due to one thing: intermittent fasting.
When calorie restricted, lab animals are typically fed once a day, and they're so hungry, they eat all of their food at once, fasting until their next feeding.

That means that the benefits may be due to fasting, not food restriction.
Fasting alone duplicates many of the metabolic effects of CR.

How long would a human need to fast to get these benefits?

Probably a minimum of 16-18 hours, with longer being better.
pubmed.ncbi.nlm.nih.gov/8238506/
Read 7 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
13 Apr
Insulin resistance is by far the most important cause of coronary artery disease.

Most other factors involved are related to insulin resistance.

Yet doctors just want to lower your cholesterol.

care.diabetesjournals.org/content/32/2/3…
To flesh this out, insulin resistance is responsible for 42% of heart attacks.

The other factors:

hypertension, 36%
HDL, 31%
BMI, 21%
LDL, 16%
triglycerides, 10%
fasting glucose, 9%

are all related to insulin resistance.

And smoking (9%) causes insulin resistance.
Even the last factor, family history at 9%, is related to insulin resistance.

Yet many people report that when they ask their doctor for a fasting insulin level, the reply is "I wouldn't even know what to do with that."
Read 5 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
13 Apr
New study: Neither high LDL-C nor HDL-C levels were significantly associated with future CV mortality in older adults aged ≥ 65 years.

High LDL-C levels do not seem to be a risk factor for CVD in elderly individuals.
lipidworld.biomedcentral.com/articles/10.11…
The risk of mortality, MI, and stroke was high at low HDL-C levels in the Korean population, but extremely high HDL-C levels were not associated with an increased risk of mortality, MI, and stroke.
Read 4 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
5 Apr
Body composition, which is the relative proportion of muscle to body fat, rules health.

Metabolic syndrome and type 2 diabetes, are closely linked to body composition.

Thread 👇
526 apparently healthy adults were grouped in tertiles (equal thirds) of muscle/fat ratio (MFR), from highest to lowest.

Those with lowest MFR had 5.4 times the odds of metabolic syndrome. Image
Data source: diabetesresearchclinicalpractice.com/article/S0168-…
Read 14 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
24 Mar
Why exercise is ineffective for weight loss

Thread 👇
Burning calories

Exercise doesn't burn as many calories as most people think.

A 5-mile run, which is a considerable amount of exercise, burns about 500 calories.

But that's only 400 more calories than if you just sat on your backside doing nothing.
You'd need to run ~35 miles to lose one pound of body fat, assuming you ate no more than if you hadn't run 35 miles.

Surely there must be a better way.
Read 10 tweets

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