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Dr Vikram Sakaleshpur Kumar 🇮🇳 Profile picture
@vikkypaedia
May 22, 2021 • 7 tweets • 8 min read • Read on X
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Inadvertent Pumping in too much of Zinc!could this also be contributing to this epidemic of #mucormycosis #blackfungus in association with other risk factors...!? @MoHFW_INDIA @ProfSomashekhar @BagaiDr @iiscbangalore @ShamikaRavi @ICMRDELHI @ARanganathan72
ncbi.nlm.nih.gov/pmc/articles/P…
ipen.br/biblioteca/200… is this coincidental...!! Image
ncbi.nlm.nih.gov/pmc/articles/P… we seem to be pushing the already susceptible by feeding the #BlackFungus with more and more #zinc by negating the “nutritional immunity”... ImageImage
nature.com/articles/s4158…. In this article about High-dimensional characterization of post-acute sequelae of COVID-19, a peculiar thing to note is about the incidence of sequelae and their association with #zinc ...! Coincidental? #Mucormycosis #BlackFungus @EricTopol Image
doi: 10.1093/femsre/fux050 quite a lot of important evidences point towards inadvertent usage of #zinc and its contribution to this #Mucormycosis #BlackFungus menace.. @ICMRDELHI @MoHFW_INDIA need to probe further & till then to stop this blanket administration of #zinc to all ImageImage
blogs.scientificamerican.com/lab-rat/how-fu… a fantastic blog on how fungi steal #zinc from a #human #cell
To summarise.... these factors could be at play... needs to be validated though Image

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More from @vikkypaedia

Dr Vikram Sakaleshpur Kumar 🇮🇳 Profile picture
Mar 18, 2023
An otherwise healthy 8 yr girl presents with a 2wk h/o asympt skin eruption. A wk before the onset, she had experienced mild fever, sore throat, & coryza for which she received symp Tx without any significant sequelae.
Guess what folks..!
#MedTwitter #idtwitter #MedEd #FOAMed ImageImageImageImage
-A h/o similar complaints was also elicited in some of her school friends
-The lesions were not associated with any atopic diathesis, preceding inflammatory dermatoses, drug intake, or suggestive systemic finding.
-O/E, multiple discrete hypopigmented macules & patches of varying sizes (0.5-1.5 cm) without any surface change were seen to be distributed symmetrically involving the dorsal & ventral aspects of bilateral lower limbs
Read 10 tweets
Dr Vikram Sakaleshpur Kumar 🇮🇳 Profile picture
Mar 17, 2023
Ibuprofen is commonly used in #neonates with PDA, but its benefit is uncertain.
this is a multicenter, noninferiority trial, PDA (dia, >1.5 mm, with L-R shunting) who were extr preterm (<28 weeks’ GA) to receive either expectant management or early ibuprofen Tx
#MedEd #MedTwitter
The noninferiority of expectant Mx as compared with early ibuprofen Tx was defined as an abs risk diff with an upper boundary of the one-sided 95% CI of < 10 %ge pts.
A total of 273 infants underwent randomization. The median gestational age was 26 weeks, and the median birth weight was 845 g.
Read 11 tweets
Dr Vikram Sakaleshpur Kumar 🇮🇳 Profile picture
Mar 15, 2023
Some very interesting dev in the Tx regimens for #TB especially the common rifampicin susceptible TB
@MoHFW_INDIA @DHFWKA @ICMRDELHI @StopTB @UNICEF @paimadhu
#MedTwitter #idtwitter
The imp points 👇 Image
There were 4strategy groups with diff initial regimens; noninferiority was assessed in the 2 strategy groups with complete enrollment, which had initial regimens of high-dose RIF–linezolid & bedaquiline–linezolid (each with INH, PZA,& ETH).
-The primary outcome was a composite of death, ongoing treatment, or active disease at week 96.
Read 7 tweets
Dr Vikram Sakaleshpur Kumar 🇮🇳 Profile picture
Feb 3, 2023
Folks....!
A 4 month -old girl infant
▶️of consanguineous parents
▶️one of her brothers died at the age of 2 mth due to #SIDS with the other brothers being normal; presents with
▶️Dysmorphic features
▶️growth faltering
#MedTwitter #FOAMed #TipsForNewDocs
▶️Delivered by LSCS section at 38 wk gest due to intrauterine growth retardation.
▶️birth weight 1240 g, length was 37.3 cm , head circumference was 30.5 cm
▶️At the age of 12 days, she was admitted for suspected sepsis for a week and discharged in good general condition.
▶️Now at 4 months, severely growth retarded with normal mentality,
▶️weight 2.5 kg, length 47 cm ; head circumference 36 cm (all growth parameters below the 3rd centile).
Read 14 tweets
Dr Vikram Sakaleshpur Kumar 🇮🇳 Profile picture
Feb 3, 2023
Folks...
Have you all seen anything like this before..!?
What could this be?

#MedTwitter #FOAMed #TipsForNewDocs #MedEd Chest X-ray with posteroanterior and lateral view shows a pa
▶️A 57-year-old man of Javanese ethnicity, Indonesia, with a 12-year history of progressive shortness of breath on exertion
▶️there were inspiratory coarse crackles & occasional wheezing with⏬vesicular sound across all thoracic areas, more in the bilateral base of the lungs.
▶️Cardia was unremarkable, with observable clubbed drumstick appearance of the fingers, without cyanosis or peripheral edema
▶️heavy smoker, around 40 pack-years.
▶️previous h/o completed treatment of pulmonary Tb in 2018.
Read 14 tweets
Dr Vikram Sakaleshpur Kumar 🇮🇳 Profile picture
Feb 2, 2023
A 4-week-old male infant born at 33 weeks of gestation presented with this. Observe the child's 👀 carefully ... what is happening to the eyes while its mouth opens and closes?
#MedTwitter #MedEd #TipsForNewDocs #Pediatrics #FOAMed
@Sthanu5 @AvrahamCooperMD @PaediatricFOAM
▶️The mother's pregnancy was complicated by maternal syphilis and methamphetamine exposure.
▶️The baby subsequently was found to have a positive serum RPR (1:4) & positive VDRL in CSF (1:1)
▶️GE - hepatomegaly & syphilitic rhinitis (snuffles)-
▶️Diag: Neurosyphillis
▶️Synkinetic jaw movement with blinking - Marcus Gunn jaw-winking syndrome, a congenital cranial innervation disorder wherein a usually ptotic eyelid elevates with mouth opening.
▶️Other names :- trigemino-oculomotor synkinesis and pterygoid-levator synkinesis.
Read 9 tweets

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