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Shane Crotty Profile picture
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25 May, 6 tweets, 2 min read
Moderna vaccine works in teenagers!
🔵 Immune responses as good as adults
🔵 Same side effects as adults
🔵 Data will go to FDA for approval now
🧵
apnews.com/article/modern…
Overall, the Moderna and Pfizer vaccine results have been virtually identical for protection and immune responses, so these results in teenagers are not a surprise, since the Pfizer vaccine did great in teenagers.
But the Moderna results are still really good to see! Two independent vaccines in parallel getting the same results gives a lot of confidence about the protection!
In both the Modern and Pfizer trials there were ZERO cases in the vaccinated kids (22 cases in unvaccinated), so a simple perspective is that the two vaccines are essentially identical and are extremely effective at preventing infections in teenagers.
investors.modernatx.com/news-releases/…
This Moderna trial had fewer COVID cases than the Pfizer trial, most likely simply because there was a lot more COVID in America during the Pfizer trial, which happened earlier.
Will see the data publicly in detail once it goes to the FDA.

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More from @profshanecrotty

Shane Crotty Profile picture
26 May
I gave a short talk today at a WHO symposium on COVID-19 vaccine correlates of immunity. It was an excellent conference. My role was to highlight and discuss potential roles of T cells in vaccine mechanisms or correlates of protection. 🧵
I decided to record a copy of the presentation, posted above.
The conference was organized by Stanley Plotkin
As part of the talk I show this model. The concept here is that as variant divergence increases, the amount of the protective immunity provided by neutralizing antibodies decreases, but the amount of protective immunity provided by memory T cells and B cells is preserved. Image
Read 6 tweets
Shane Crotty Profile picture
22 May
Vaccination of immunocompromised or immunosuppressed people against COVID is a major topic now.
I think this is good simple advice:
"Get vaccinated, but behave as though you're not," Dorlan Kimbrough, a neurologist who treats multiple sclerosis patients at Duke. 🧵
It is early days for understanding and advice on this, but thankfully there are already scientific studies (preprints) being published on COVID vaccine immune responses in such patients. These are two good new news articles on the topic:
advisory.com/en/daily-brief…
and
washingtonpost.com/lifestyle/2021…
Read 11 tweets
Shane Crotty Profile picture
21 May
My current take on RNA vaccine likely protection against B1617 (Indian variants)

nbcnews.com/health/health-…
“The fact that there is real-world data that shows the Pfizer vaccine works very well against the South African variant, it's quite likely that both the Pfizer and Moderna vaccines will be very effective against these new Indian variants, as well,”
That is based on:
🔵 data from Qatar against B1351 (97% protection against severe disease, 75% against infection)
🔵@SutharLab B1617 neutralizing Ab data
🔵L452R containing CAL.C20 variant antibody data
Read 7 tweets
Shane Crotty Profile picture
20 May
My comments on an excellent new study on delaying the 2nd dose of Pfizer COVID vaccine to 3 months, in people over 80. 🧵

A well done story by local journalist @DerekStaahl.

10news.com/news/in-depth/…
Overall, this new delayed dose vaccine study it is a high quality study. Bottom lines: 
🔵 The UK delayed vaccination is working for them, and allows vaccination of more people. And the new data support that. I am really happy about that!
🔵 But, if you have enough doses, getting the 2nd dose on the recommended schedule is still probably better.
Read 10 tweets
Shane Crotty Profile picture
12 May
For people on the fence about getting the COVID-19 vaccine for their kids, given the approval today, here is COVID-19 vaccine information. 🧵
1/ Kids get COVID-19, including very serious disease.

There were over 35,000 kids hospitalized with COVID-19 in America this past year.

Among pediatric hospitalization cases, 50% had no risk factors.

covid.cdc.gov/covid-data-tra…
2/ The vaccine is incredibly successful in kids 12-15, and very safe
Read 4 tweets
Shane Crotty Profile picture
11 May
The FDA expanded the Pfizer/BioNTech RNA COVID-19 vaccine to 12-15 year olds yesterday.
🔵Excellent protection (100% = 0 cases versus 18)
🔵Excellent safety (On to younger children already)
🔵Better antibodies than adults

Also bodes well for other COVID vaccines in kids!🧵
FDA CBER head Dr. Marks:"It was a relatively straightforward decision. The response..was excellent and in fact it was even better, really, in the younger age group than it was in the 16-25 age group. The safety profile was very similar in 12-15-year-olds as in 16-25-year-olds."
fda.gov/news-events/pr…
Read 8 tweets

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