Some cool #Syphilis Pearls from an article that @k_vaishnani shared ncbi.nlm.nih.gov/pmc/articles/P… Primary syphilis first manifests into a painless chancre at the site of inoculation 1 to 6 weeks later…
Hematogenous dissemination then can occur typically 4 to 10 weeks later, giving rise to secondary syphilis. <40% of pts w/ syphilis have primary syphilis diagnosed. These “Secondary” lesions last for several weeks before spontaneously resolving. Coined “early, latent infection”
What does late infection mean? When syphilitic lesions recur after 1 year from the initial eruption, or seropositivity is detected more than 1 year after the initial eruption, it is termed late latent syphilis.
What’s rupoid syphilis? A rupioid presentation consists of large plaques with darkened, heaped-up mounds of crust and scale resembling the back of an oyster shell.
Just a reminder: an RPR is a non–treponemal-specific test that detects antibodies to lecithin cholesterol antigen. There can be False +’s, confirm test w/ a treponemal-specific test, FTA test (remains + for life). RPR titers decrease w/ tx & should be used to detect tx response.
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