This is fantastic! Real-world data out of Butantan Institute São Paulo, Brazil shows after ~75% of Serrana’s population had been vaccinated with Coronavac:

•95% reduction in deaths
•86% reduction in hospitalizations
•90% reduction in IC
•80% reduction in symptomatic cases
Total vaccinated population: 27,150 (97.7% of adult population vaccinated with first dose; 95% vaccinated with second dose). Keep in mind, this is in the face of variants of concern including P.1. 75% of Serrana’s population had been vaccinated with Coronavac from February-April.
For comparison purposes, Serrana was compared with Jardinópolis, a nearby city. The death curves were similar UNTIL Serrana began vaccinating. After vaccination (first graphic), we can see deaths rose in Jardinópolis (blue) but dropped significantly in Serrana (orange).
Other important factors to come out of this study: the results showed that vaccination protects not only the adults that received two doses of the vaccine but ALSO children and teenagers younger than 18 years-old who were NOT vaccinated.
Another important conclusion of this study is the incidence of disease in Serrana in comparison with nearby cities. Serrana has around 10,000 residents that work in Ribeirão Preto daily. However, while Ribeirão Preto and other cities within the region are presenting
high levels of COVID-19 cases, Serrana maintained low case numbers when compared to the cities with similar profiles due to vaccination. In other words, the success of vaccination was confirmed not only by the decrease in the number of infected individuals but also for the fact
that residents of Serrana that travel daily from one city to another did not bring a relevant increase to the number of cases! The study also concluded that the last two groups to be vaccinated were already benefiting from the reduction in transmission of the virus generated
by the immunization of the residents of the two first groups! Overall, very encouraging! While we wait for the full study documents, details can be found here:… H/T: @gutoaqui
NOTE: Coronavac is Sinovac’s vaccine!

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More from @sailorrooscout

29 May
This is so encouraging! A recent study demonstrates detection and longitudinal persistence of SARS-CoV-2 IgG antibodies in the upper respiratory tract following COVID-19 vaccination. What does this mean? Prevention of SARS-CoV-2 infection AND transmission! Let’s discuss!
Researchers enrolled 114 individuals who had received their first dose of Moderna’s vaccine within 3-7 days and collected oral mucosal fluid samples on days 5, 10, 15, and 20 after each vaccine dose. Of those who were naive (no history of previous infection) to SARS-CoV-2
(n = 89), 79 (85.4%) tested positive for SARS-CoV-2 IgG antibodies by time point 2 (10 days +/-2 days after first vaccine dose), and 100% tested positive for SARS-CoV-2 IgG by time point 3 (15 days +/-2 days after first vaccine dose). And that’s with just one dose!
Read 13 tweets
26 May
Immunological memory for the win! Two new studies show immunity to Coronavirus lasts AT LEAST a year, possibly a lifetime, AND improves over time, ESPECIALLY when paired with vaccination!
The first study shows those who had been previously had an infection have cells that retain a memory of the virus persist in their bone marrow and produce antibodies whenever needed, demonstrating a SARS-CoV-2 infection induces a robust antigen-specific,
long-lived humoral immune response in humans. Find that study here:…. The second study is still being reviewed before publication in Nature but found memory B-cells continue to mature and strengthen for at least 12 months after initial infection!
Read 4 tweets
26 May
A study from Indraprastha Apollo Hospital in Delhi on 69 HCWs vaccinated with Covishield (AZ) who tested positive post vaccination shows:
•Vaccines helped prevent severe illness and hospitalization
•NO deaths, NO ICU admissions
•B.1.617.2 was sequenced in 48% of cases
Amongst the 69 HCWs, 51 were fully vaccinated with two doses (74%) and the remaining 18 (26%) were partially immunized with a single dose, prior to being infected. The predominant infections occurred from B.1.617.2 lineage (48%), followed by B.1 and B.1.1.7 strains.
There were only two hospital admissions (2.9%) for minor symptoms, but NO ICU admissions and NO deaths, from this group. These findings are significant because more than half of the cohort were found infected with B.1.617.2 and were still protected from severe illness,
Read 7 tweets
23 May
Let’s clear up some confusion. Concerning AstraZeneca against B.1.617.2 and those reporting it is only 60% effective, let’s stop. It’s ONLY 60% at 21 days post-second dose follow-up. At the 11-12 week follow up, one would expect it to be closer to 80-90% range. Why? See here.
Also, NO, it doesn’t take AstraZeneca 12 weeks post-second dose to achieve efficacy either. So don’t get confused. Remember that rollout of second doses of AstraZeneca was later than Pfizer in the UK. In this PHE analysis from last night, most (74%) people had only just recently
(past 28 days) had their 2nd AZ doses, vs. less than half (46%) of Pfizer, and half of them had it more than 28 days ago. So for example, B.1.1.7, when you’re looking at this chart. AstraZeneca 2 doses after 28 days is 66%. AstraZeneca second dose AFTER 12 weeks is 85-90%.
Read 13 tweets
18 May
I honestly never thought I would see the day I was shamed by other academics for only having a Masters degree. I have hit a roadblock saving to be able to even pursue a PhD while I have been helping my family during COVID. Not having one doesn’t mean I am unqualified to speak.
Those who know me know how much I went through to make it through school with what I had and what my family had. I didn’t grow up with money. I am still paying off my student loans but I’m still trying and will continue to do so. I am proud of how far I have gotten.
Some have asked who and I shouldn’t be worried about shielding these people. I’m tired. I do the best I can with what I have right now. Getting a PhD is a luxury that I cannot meet the needs for yet. Image
Read 5 tweets
18 May
This is wonderful! Real-world study data out of UCL based on 8,517 people in England and Wales shows 96% of people, who had either Pfizer’s or AstraZeneca’s vaccine developed antibodies 28 to 34 days after their 1st dose. This rose to 99% within 7 to 14 days of their second dose!
Over 9 out of 10 adults in the UK who had either the Pfizer or AstraZeneca vaccine produced antibodies against the virus within a month of their first dose. None of the participants of the study had antibodies prior to their first dose of the vaccine. The study found antibody
rates initially increase quicker among those who have had the Pfizer/BioNTech vaccine than those with the Oxford/AstraZeneca. However, after one month the recipients showed almost identical antibody positivity rates.
Read 6 tweets

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