✅ENFERMEDAD DE CROHN (1/5)
👉🏼Afecta de boca-ano
👉🏼Tabaquismo (factor de riesgo)
👉🏼Patrón bimodal (15-25 años y 55-65 años)

🔹Genética: HLA-A2
🔹Ac. ASCA

👉🏼Triada clínica
1)Diarrea crónica
2)Dolor abdominal
3)Pérdida de peso

#ENARM #ENARM2021
✅ENFERMEDAD CROHN (2/5)
👉🏼50% respeta recto
👉🏼Enfermedad perianal (fístulas, úlceras,etc)
👉🏼Obstrucción intestinal

👉🏼Manifestaciones extrintestinales:
-Eritema nodoso ❗️
-Litiasis oxalato de calcio
-Anemia hemolitica
-EA (asoc. HLA-B27)

#ENARM
✅ENFERMEDAD CROHN (3/5)
👉🏼Dx:
1) Transitó intestinal (inicial)
-Imagen “manguera de jardín)

2)TAC (elección)
3)Colonoscopia + biopsia
-Confirma Dx (histologia)

#ENARM2021 Image
✅ENFERMEDAD DE CROHN (4/5)
👉🏼Endoscopia:
-Alteración en “parches”
-Mucosa aspecto “empedrado”
-Úlceras profundas y fisuras

👉🏼Histologia:
-Distorsión de criptas
-HIPERPLASIA linfoide transmítala
-Granulomas NO caseificantes ImageImage
✅ENFERMEDAD CROHN (5/5)
👉🏼Tx:
1) Inducción a remisión
-Leve: mesalazina
-Moderado/grave: Budesonida

2)Mantenimiento
-Azatioprina
-6-mercaptopurina
-MTX

3)Refractaria
-Infliximab o adalimumab

🔹Fístulas: seton+ antibiótico y Tx remisión
#ENARM2021

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