Good to see that 45.7% of adolescents in this study did not have primary reason for admission be related to COVID-19 which is consistent with careful work done by our Stanford & Northern California colleagues that 40% admissions in children not for COVID
cdc.gov/mmwr/volumes/7…
That work is summarized here in a commentary I wrote with @DrAmyBeck - careful chart review find reasons for 40% hospitalizations in children during pandemic linked to other reasons (consistent with 45.7% in this study) hosppeds.aappublications.org/content/early/…
Those carefully done studies with chart review are here so you can look at them for yourself
hosppeds.aappublications.org/content/early/…
here is 2nd paper in same edition, Hospital Pediatrics. Consistent with this CDC data that admissions for COVID for children, 40-45.7% misclassified. Form policy (2nd dose delay?) carefully after ACIP reviews myocarditis cases from UW in young after dose 2
hosppeds.aappublications.org/content/early/…
Always be careful about children: 1) carefully adjudicate reasons for hospitalization in young people & assure if for COVID-19, not due to universal screening with PCR positivity in nose; 2) ACIP- evaluate Seattle myocarditis cases, see if delaying 2nd dose in 12-15 good strategy
Also, one thing I noticed reporters may not know: we do not screen everyone for flu when they enter a hospital in winter for something else. We screened everyone for COVID in their nose when they got admitted for infection control purposes. This is why this CDC study noting 45.7%
of admissions were not for COVID but other reasons (psychiatric in 44%) and the two Hospital Pediatrics studies @DrAmyBeck I reviewed were so important. We do not misclassify flu hospitalizations in children in 2018, 2019; we misclassified COVID admissions in children in 2020
And one final thing & you may have noticed I try to be calm here usually: it is NOT okay for a poorly done CDC MMWR study nor reporters to scare parents. If you report data accurately, people will still follow appropriate precautions when needed; get vaccinated; not ok to scare

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More from @MonicaGandhi9

5 Jun
MYOCARDITIS after 2nd dose of COVID vaccine after 2nd dose mainly among 12-17 year olds in US. Data from Vaccine Adverse Events Reporting System (VAERS). Remember, vaccines can cause myocarditis. The rate of myocarditis from smallpox vaccine was 1/12,000: jamanetwork.com/journals/jama/…
Mechanism unclear (handwaving paper says "antibodies & T cells"). Now remember, only Pfizer is approved for 12-17 year olds and the dose of the vaccine (30 micrograms) is the same dose used for adults (the trials among kids 6 months-11 years uses lower dose, 10). Publicly
available data from VAERS up to 5/28/21 shows myocarditis rate post vax for16-17 yo is 0.0016% (so comparable to smallpox). In fact, hospitalization for myocarditis post-vax among 12-17 year olds is currently 12x greater than hospitalization for COVID with low cases among
Read 12 tweets
1 Jun
These days in U.S., asked what end of epidemic would look like & I wanted to explain why COVID - once controlled- will be more like measles (where public doesn't think about every day) than influenza (where public does think about in winter). COVID has highly effective vaccine
like measles does - the effectiveness of the measles vaccine is high like the effectiveness of the COVID-19 vaccine - one dose 93% effective and two doses 97% effective per original studies. We give measles vax
fda.gov/consumers/cons…).
two doses in childhood & then high exposure populations like healthcare workers/international travelers often given booster - schedule is here. We have already discussed that T cells from measles vaccination last a long time -remember paper
cdc.gov/vaccines/vpd/m….
Read 13 tweets
31 May
With 0 deaths across England from COVID today, I am reminded that on April 22, 2021, England downgraded its epidemic to "endemic" status when an infection no longer is causing morbidity/mortality to justify extreme measures adopted earlier without vax
news.yahoo.com/covid-pandemic…
Now the UK is at 58% 1st dose and we are at about 50% 1st dose because they adopted a 1st dose first strategy so going faster than we - please see World Vaccine tracker here. And UK does a lot of testing & has seen B.1.617 but has not changed 0 death mark
ourworldindata.org/covid-vaccinat…
You can see and track cases/hospitalizations/deaths here at Worldometer across regions & this is what UK rate looks like. When hospitalizations/deaths become DECOUPLED from cases with vax, not prudent to track cases as metric of re-opening (or variants)
worldometers.info/coronavirus/co…
Read 5 tweets
29 May
Wanted to talk to you about our #inoculum hypothesis and may have particular relevance in the vaccine era. Our idea was -after seeing that mitigation procedures like masks didn't always block transmission especially if just cloth or plain surgical, but seemed associated with less
severe disease and more asymptomatic infection - was that if you are exposed to less viral inoculum or dose, more likely to get mild disease. We first explored this hypothesis here and then, given that even asymptomatic or mild infection triggered T cells,
link.springer.com/article/10.100…
we hypothesized that anything that would drive the infection towards asymptomatic or mild (if unlucky enough to be exposed) while awaiting a vaccine was helpful -e.g. nonpharmaceutical interventions (NPIs) like masks nejm.org/doi/full/10.10…
Read 9 tweets
28 May
The @CDC guidance on outside masking has changed!
I am so relieved. Let's take this victory for now towards a science-based approach to outside masking for children in camps this summer & keep working towards rest once I take a little break from this my friends.
news.yahoo.com/cdc-relaxes-gu…
By the way, this guidance means no unvax person has to make outside as per the science. This is good to be aligned with WHO who has been so right on so many things (natural immunity, children <5 don't need to mask, no outside masking unless crowded)
wsj.com/articles/take-…
Read 4 tweets
28 May
Due to need to go back to my "real work" in academia, I will be taking short break from Twitter. However, if interested, I tried to summarize my thoughts on why we won't need boosters anytime soon in this article technical-leaps.org/booster-shot/ and less washingtonpost.com/outlook/2021/0…
In terms of COVID origins, effectiveness of the vaccines & why CDC messaged what they did (of course you still can mask if more comfortable as individual choice) & global vaccine equity please watch this segment from @democracynow
democracynow.org/2021/5/27/covi…
Much confusion about children should not be masked outdoors this summer & return to normal life (with masks removed in school like UK once hospitalization or cases low in area)- Explain in voice on @NPR & print in WaPo
washingtonpost.com/opinions/2021/…
npr.org/podcasts/47885…
Read 4 tweets

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