New evidence for how well vaccinations are working to block delta's (B.1.617.2) harm
In the UK, it's only in the younger age group for which hospital admissions are increasing… @FT @mroliverbarnes
And the @FT analysis of 1st dose vaccine efficacy vs. delta looks better than the original ~30% calculation 👍
A new 🧵from @jburnmurdoch gets into more data and depth

• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with Eric Topol

Eric Topol Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @EricTopol

6 Jun
With a strong vaccination campaign, the United States was able to reduce the B.1.1.7 (alpha) variant's toll to a bump in cases
What might happen with B.1.617.2 (delta) which is ~50% more transmissible, and more evasive to our immune response? /1
It will be hitting us with a far less case burden, as we approach containment for the 1st time.
But still much vulnerability d/t half the population unvaccinated and ~40% fully vaccinated
2 doses appear to be needed to get to high ~90% effectiveness /2
We'll likely see a bump in cases and adverse outcomes (magnitude uncertain) largely among unvaccinated, and a challenge to get to containment in a fully reopened country, prolonging the pandemic here /3
Graphic adapted from @tomhcalver @thetimes
Read 4 tweets
4 Jun
The extraordinary book, The Premonition, by Michael Lewis, is the subject of our conversation. It gets behinds the scenes of public health/CDC long before and during the pandemic. We spoke just days before the fatal car accident of his 19-year-old daughter…
Our deep condolences.
He had no hesitation for this discussion to be posted —he really wants the story to reach the medical community.
It stitches together these people. Michael is perhaps the best storyteller of our era; it's truly fascinating and germane pre- & intra-pandemic Image
Lewis traces back 15 years before the pandemic to show the inadequacies of the CDC and US public health resources. CDOR Center for Disease Observation and Reporting. The metaphor of watering plastic flowers Image
Read 4 tweets
27 May
The B.1.617.2 variant has now become dominant in the UK, associated with rising hospital admissions. It's also starting to rise in the US. While vaccinations protect against it, the 1st dose has only ~30% efficacy.
See @jburnmurdoch's new 🧵
It is looking more and more like B.1.617.2 will be the next challenge for the US fo face w/ only 40% of its population fully vaccinated and 50% with 1 dose.
The advance UK warning on B.1.1.7 led to aggressive US vaccination which fended off a new (4th) surge.
Can we rally again?
"Of 49 people hospitalized with the new variant in Bolton, only 5 have been vaccinated with both doses"…
Recall 2 dose efficacy vs B.1.617.2:
mRNA (@Pfizer) 88%
@AstraZeneca 60%…
Read 4 tweets
24 May
Just published @Nature
After even mild covid infections there are, in addition to memory B cells, bone marrow plasma cells are induced to provide long-term protection > 1 yr…
@TheBcellArtist @WUSTLmed
(NB vaccination still provides further protection) Image
I'm thinking of the participant donors of this study who had a bone marrow aspirate (and many twice) so we could learn from them. A very tough procedure to go through once, no less twice, to advance science. Heroes and good to see they were acknowledged Image
More on this enduring, likely multi-year protection derived from covid vaccines or infections, indexed to this paper… by @apoorva_nyc
Read 4 tweets
15 May
A current status comparison between California, the US state with lowest covid cases/capita, and the UK
Although the 1st dose of vaccination rate is comparable, California has >5X test positivity, >3X hospitalizations, and 10X deaths
Potential explanations for these gaps include: (1) the faster rate the UK achieved their 1st dose vaccination and lag time to see the effect in CA, and (2) more aggressive mitigation measures used in the UK
and (3) important point was the strict by age UK vaccination roll out, now 38+ years, whereas the US only used that strategy initially
Read 4 tweets
15 May
There are many misconceptions about the Yankee cluster of post-vaccination infections. We can learn from the best studied cluster in a skilled nursing facility of 46 such cases with genomic sequencing of the virus from 28 @CDCMMWR /1
This outbreak was indexed to 1 unvaccinated individual with overdispersion (superspreader); no indication of transmission between the others. The mRNA vaccine effectiveness of 94.4% vs severe illness among elderly residents is striking /2
A variant (R.1) w/ E484K mutation was noted in all cases sequenced
Let's contrast w/ the 8 Yankees post-vaccination infections who had PCR testing 3 times a day, 7 of 8 have had no symptoms, and we have no denominator of non-cases or genomic sequencing. Very incomplete! /3
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!