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Andre Watson 🧬 Profile picture
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14 Jun, 4 tweets, 1 min read
For anyone wondering what the biodistribution data of Pfizer/BioNTech mRNA nanoparticles looks like, you can see pages 6-7 here:

files.catbox.moe/0vwcmj.pdf
Important to note that the left diagram is “mean total lipid concentration,” while the smaller organs in the right diagram are “total lipid concentration.” One measure average detection in each organ for each rat, while the other measures total activity of combined rat organs.
Also, this does not look at gene expression of the mRNA — only distribution and degradation of the radiolabeled lipids — and the liver would be expected to degrade lipids accordingly.

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More from @nanogenomic

Andre Watson 🧬 Profile picture
25 May
There will need to be separate diagnostic criteria for long-COVID sufferers and for those who recover from COVID and have long-lasting secondary effects... this will require new drugs and biologics to rejuvenate damaged tissues, not just manage viral load.
Additionally, edge cases which will be increasingly more common e.g., autoimmunity (whether precipitated by COVID or pre-existing and exacerbated) — will require new looks at autoimmune dampening strategies.
It would be a bad move to simply continue classifying COVID as a binary outcome of survival vs. death, and hospitalization or not. Our entire healthcare system needs to be revamped to prioritize improving people’s health and preventing chronic conditions, not just treating them.
Read 10 tweets
Andre Watson 🧬 Profile picture
28 Apr
Nicotine exhibits 6.6-fold stronger binding for ACE2 in the presence of the SARS-CoV-2 spike protein, and reduces the binding affinity of the spike protein for the ACE2 receptor.

ncbi.nlm.nih.gov/pmc/articles/P…
The effects of nicotine on increasing antibody binding affinity to the SARS-CoV-2 spike protein in competition with ACE2 should also be explored.
With new variants exhibiting even stronger ACE2 binding than the original strain of SARS-CoV-2, and while coupling these findings to the decreased binding affinity of neutralizing antibodies to some of the new strains, nicotine may end up serving an immune-enhancing purpose.
Read 7 tweets
Andre Watson 🧬 Profile picture
27 Apr
An analysis of 96,057 COVID-19 cases among a ~1.5 million population between March and December of 2020 found a 50% increase in cases during days of low wind speed (<5.5mph) than on days of high wind speed (>5.5mph).
This is an argument for mask wearing.

medrxiv.org/content/10.110…
It will be good to see more data that accounts for individual time spent outdoors versus indoors over the course of a week or two, and integrating contact tracing data and the like. And, creating better assays in outdoor environments to simulate breathing and exposure thresholds.
In the above study, they adjusted an 8-day moving average case count to account for lag between infection and presentation of symptoms.
Read 4 tweets
Andre Watson 🧬 Profile picture
27 Apr
Some research on changes in neutralizing antibody potency of some SARS-CoV-2 variants of concern (VOC): namely, 1) E484K, 2) N501Y, 3) ∆69/70 + N501Y + D614G, and 4) E484K + N501Y + D614G. Out of these VOCs, E484K mutants are showing greatest escape potency for vaccinated serum.
E484K:
"SARS-CoV-2 spike E484K mutation reduces antibody neutralisation"
thelancet.com/journals/lanmi…
N501Y:
"The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera"
medrxiv.org/content/10.110…
Read 18 tweets
Andre Watson 🧬 Profile picture
27 Apr
Recalling a conversation with a successful biotech founder who had raised several hundred million with 2x exits, asking what I can do to move things forward faster. He told me to stop and smell the roses.

Good reminder that working more doesn’t always make things move faster.
Certainly, the founder mindset should be “what else can I do,” and setting up to do the critical things at superhuman speeds. At the same time, especially when it is a long game, the clarity of silence and resetting your mind can lead to hyper-productive, time-saving insights.
“[W]e've come to believe that world-class performance comes after 10,000 hours of practice. But that's wrong. It comes after 10,000 hours of deliberate practice, 12,500 hours of deliberate rest, and 30,000 hours of sleep.”

theweek.com/articles/69664…
Read 6 tweets
Andre Watson 🧬 Profile picture
16 Apr
Compiling some research on risk of antibody-dependent enhancement (#ADE)...

It's important to emphasize that this does not reflect support of vaccine hesitance, and that the data on vaccine efficacy is extremely good.

[Thread on recent scientific articles to keep in mind...]
It would be good to include broader antibody panels separating "good" neutralizing antibodies from potentially deleterious antibodies and correlating this to strain emergence... the concern is not just the neutralizing sites at the ACE2-binding interface and "good" antibodies.
While the public health benefit of vaccines is huge, and COVID is orders of several magnitude more dangerous to older populations than vaccination, we should remain vigilant about these potential issues emerging over time, and preempt the problem with better immunomodulators.
Read 17 tweets

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