AJ Leonardi, MBBS, PhD Profile picture
Jun 16, 2021 5 tweets 3 min read Read on X
This is concerning.

When controlling for age, body habitus, and other variables, people who had covid had sizes of key brain structures 4 standard deviations below average.

The hippocampal gyrus is responsible for memory, in part.
medrxiv.org/content/10.110… ImageImage
These changes were not found to be different whether one was hospitalized or not.

The one metric where size increased post covid- ventricle volume- is a good marker for loss of brain matter. This usually increases with age. ImageImage
And before people tell you this was unexpected- no. This was predictable. Furin cleavage sites confer neurotropism and this was my primary concern with the virus. With the knowledge it had a Sag, the situation appeared more dire. Downplayers are culpable. Image
I have been trying to convey this clear risk to people like Prasad and Munro who advocate to have kids in classrooms despite circulating neurotropic viruses with furin cleavage sites and superantigens. Image
Whether intentional or not, it seems to me all pathologically salient features of the virus like the Furin cleavage Site and SEB Superantigen were downplayed bc they went hand in hand with stoking the possibility of modifications a lá Gain of Function, whether true or not.

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More from @fitterhappierAJ

Jan 4
In August an immunologist declared the "Leonardi Effect" had received a "decent burial"

Fast forward to today: a new preprint shows what I warned about in 2020

Persistent SARS-CoV-2-induced impairment of CD8 T cell responses to community-acquired pathogens

I was right
1/5 Image
Key finding: Post-COVID patients show markedly reduced T cell reactivity to common pathogens (influenza, Staph, VCZ) which is evidence of lasting immune dysregulation favoring secondary infections and viral reactivation

Link:


2/5 biorxiv.org/content/10.648…Image
This is the scenario I described years ago: accelerated CD8 aging/paralysis/exhaustion/senescence, poorer control of pathogens.

We ignored it at our peril. Rising "mystery" infections, cancers, herpes flares? Not a coincidence
3/5 Image
Read 5 tweets
Jan 1
This BMJ highlight on movement from "immunity debt" to COVID's direct role in immune harm is a welcome shift

The evidence on T cell dysregulation driving secondary risks has been mounting and it's good to see mainstream outlets engaging it seriously
1/ Image
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In 2020 I argued against "debt", emphasizing Covid's lymphomanipulative pathways (T cell apoptosis, exhaustion, aging) causing immune harm

This drew massive ire
Labeled "crank"/"fraud," threats of op-eds pressuring labs, and a rescinded postdoc

I sacrificed hugely for candor
2/ Image
Detractors confidently pushed alternate explanations and villified me back then

now, as data aligns with booming opportunistics, they're silent. no acknowledgment, no "perhaps we were harsh."
3/ Image
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Read 6 tweets
Nov 5, 2025
In 2020 I wrote a paper claiming the lymphopenia in Covid included Apoptosis, or T cell death

I made this "extreme" claim after reading the 1st paper on Covid's clinical course

Now, a paper claims ongoing T cell death is shaping population immunity
1/ link.springer.com/article/10.118…
Here they start by suggesting the immune system is aging from covid and that aged immune systems are vulnerable

In 2020 I projected that if reinfections would occur, then we would be left with population-level prematurely aged immune systems
2/ Image
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Their meta-analysis concludes Covid is causing sustained T cell death

There is an alternative hypothesis that reverses causality, but it is ridiculous

However, I claimed in 2020 immune harm from covid would ↑ susceptibility to a sera-evading variant
3/ Image
Read 12 tweets
Jun 22, 2024
@Bryce_Nickels This is absolutely false because he made a “noble lie” and said the N 95s would not work for the public to the public in order for there to be greater supply to healthcare workers only. This backfired.
@Bryce_Nickels The ethical approach was the truth. This is a similar noble lie by omission that the WHO made when they refused to declare Covid as airborne in order for impoverished health systems to provide “adequate” PPE per their regulations according to WHO standards
@Bryce_Nickels The end result was workers in impoverished systems were being given “adequate “PPE for droplet transmission, and many of them died, including sadly many in New York City.
Read 4 tweets
Apr 6, 2024
When will H5N1 will go Human to Human?
Which is deadlier?
"The Covid pandemic has prepared me for an H5N1 pandemic"
Read 4 tweets
Mar 30, 2024
Wow looks like Marc is advocating Zero Covid, welcome Marc!

Mitigations like mask-wearing, clean air, and acknowledging the harm of covid infections

Well done!

This is an advancement from saying infections will maintain immunity, advocating for infection prevention instead Image
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Image
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Although it is a falsehood that vaccintions will not be needed

SARS Cov 2 is a Sarbecovirus and unlike the other common cold viruses. It has enhanced pathogenicity and immune evasion

Also, endemic sars cov 2 would INFECT the vulnerable, not protect them Image
I sure hope people didn't listen and abandon vaccinations after 1 infection because they thought reinfections would be like a common cold!
Read 5 tweets

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