Thread by @NavroopSingh_

Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity ncbi.nlm.nih.gov/pmc/articles/P…

Here I provide an assessment of potential for human pathogenesis via autoimmunity via exposure, via infection or injection.

SAR-CoV-2 spike proteins, and all other SARS-CoV-2 proteins, immunogenic epitopes in each SARS-CoV-2 protein were compared to human proteins in search of high local homologous matching.

Unintended consequences of pathogenesis from vaccines are not new, nor are they unexpected. They are unanticipated only if those who develop them do not include available knowledge in their formulation plan.

For example, the H1N1 influenza vaccine used in Europe led to narcolepsy in some patients, resulting from homology between the human hypocretin (aka, orexin) receptor 2 molecule and proteins present in the vaccine.

The fact that pathogenic priming may be occurring involving autoimmunity against multiple proteins following CoV vaccination is consistent with other observations observed during autoimmunity, including the release of proinflammatory cytokines and cytokine storm.

Similar to the SARS-CoV animal studies, found that mice vaccinated against MERS-CoV (Middle East Respiratory Syndrome) development exaggerated pulmonary immunopathology when challenged with the MERS virus following vaccination.

They reported that lung mononuclear infiltrates were observed in all groups after virus challenge, and that increased infiltrates that contained eosinophils and the eosinophil promoting IL-5 and IL-13 cytokines were observed only in the vaccinated animals.

Pathogenic priming may be more or less severe in vaccine or infection induced immune responses to some proteins than for others due to original antigenic sin;

the immunologic reaction against self-antigens may be made less severe as fast-evolving viruses evolve away from the original vaccine type.

SARS-CoV-2 has some unexplained pathogenic features that might be related to the table of putative pathogenic priming peptides.

Exposure to these specific peptides - via either infection or vaccination - might prime patients for increased risk of enhanced pathogenicity during future exposure due either to future pandemic or outbreaks or via universal vaccination programs.

This study in April 2020 actually warned priming of Human Body immune system with a Pathogen like Spike Protein of Sars-CoV-2 for purposes of Vaccines could lead to future complications and may need further studies on it.

It also talks about animal studies to be conducted to ascertain the risk of Pathogen priming like was seen in MERS. In current scenario for reference in Sars CoV 2, one can refer to Pfizer & AstraZeneca Bio Distribution studies & clinical trials on Animals.