A fab 🧵 to help you get out of bed! 1/
6/21 - bit.ly/2TbybKM#cpsvmrpearls The Ddx for lymphocytic pleocytosis is divided into Infectious causes (bacterial, viral, parasitic, fungi) and Non-Infectious causes (Autoimmune and Malignancy)
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6/22- bit.ly/35Vi32L#cpsvmrpearls We usually think of neurocysticercosis -> seizure or HA w a circle & a dot/few dots on imaging, but there is a rare form called cysticercal encephalitis that is 1. more common in young girls 2. p/w miliary cysticercosis & AMS (1/2)
In these pts., remember to avoid anti-parasitic drugs which can cause fatal cerebral edema
Tx = steroids & AEDs (2/2)
3/ 6/23 - bit.ly/3x0OCbF#cpsvmrpearls Thrombocytopenia can be interpreted as an acute phase reactant, whereas thrombocytosis suggests chronic inflammation.
When evaluating a splenic lesion, consider splenic infarct, abscess, and masses of various etiologies. As @sharminzi eloquently puts it, the spleen is like one big lymph node.
Clinical context, along with radiologic features, aids in differentiating between infarct and abscess. Identifying an abscess is crucial as it may guide treatment, which can include drainage, excision, and even splenectomy.
6/14 - bit.ly/3gR3UbQ#cpsvmrpearls Both TTP and HUS can p/w kidney injury + neurological Sx. To differentiate b/w them based on clinical Sx, remember that in TTP, the neuro Sx > renal Sx and in HUS, the renal Sx > neuro Sx
6/15 - bit.ly/3ql5IOU#cpsvmrpearls Consider CV & neuro causes when evaluating unwitnessed LOC. Presence & location of tongue bites can help differentiate b/w them: Bites on the a) lateral aspect of the tongue - seizure b) tip of the tongue - syncope c) lips/cheek - PNES
6/16 - bit.ly/35CthJt#cpsvmrpearls CNS involvement is infrequent in small & medium vessel vasculitis which commonly p/w << systemic manifestations, but when present, CNS involvement is a predictor of poor prognosis & indication for aggressive immunosuppressive Tx. (1/2)
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