Comparison of #SARSCoV2 cultures in well-differentiated, primary epithelial cells in air-liquid interface from 12 different mammals species. I'm guessing the 1 paragraph & table of Methods on the cell culture has like months of work behind it.
(fig1: left 33C, right 37C)
(fig1: left 33C, right 37C)
Since these types of cultures can be tricky and susceptible to poor cell quality they used influenza A (human isolate) and influenza D (bovine isolate) as positive controls for virus infection.
Except for 1 bat (both bats are American species), all the cultures were infectable by 1 or both #influenza viruses, showing the cells are fine, but only rhesus macaque and domestic cat AEC cells were infectable by #SARSCoV2.
Hope that spillback into American bats will not occur.
Hope that spillback into American bats will not occur.
They do dicuss that it's a bit weird that the ferret cells were not infectable (as we know that lab ferrets and farmed mink are quite susceptible) but point out that in live ferrets, infection is mainly in the nose, so airway cells might not be the right type.
forgot to paste link to paper: wwwnc.cdc.gov/eid/article/27…
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