Yoong Profile picture
2 Jul, 12 tweets, 3 min read
Seems one of the debate last few days is whether factory clusters r causing the high C19 numbers in S’gor or it’s mostly community cases now. My thoughts in this thread & will try to correct some misconceptions too.

Also, because @nadsjalil ask to. She ask, u dont say no 😂
1st of all, categorising betw factory vs sporadic cases is wrong. Sporadic ≠ community cases. Sporadic simply means unlinked, where the source of infection cant be determined. So sporadic cases could mean from community or from factory clusters.
Only way to know the source of infection for the sporadic cases is thru contact tracing, specifically backward tracing, which the PH system is overwhelmed now & cant trace back in time (more on this later). So we cant exactly know.

But what do we know about factories and C19?
First, we know factory clusters are the dominant in the new clusters. 10/21 of recent clusters are from factories.

And we know factories & living conditions of workers, especially migrant workers are high risk for transmission due to crowding.
Spillover to community is inevitable. I’ve said this since late last year during the earlier peak. If we don’t ring fence it quick enough, factory clusters will act as a super spread event/location & spread to the community.

malaymail.com/news/malaysia/…
YB Dr Afif mentioned the dominant cases now are sporadic (but we established sporadic ≠ community cases). The comparison is inaccurate.

Because we cannot look at current numbers & make a conclusion of the source of infection w/out adequate contact tracing.
For a disease like C19, we know transmissibility is uneven & our ?obsession w R0/Rt is pointing us at the wrong direction.

R is the potential transmissibility & it’s the average of the total infections. Consider this 2 situations of a R0 of 1 (1 person will infect 1 more person)
1. In a group of 100 infected person, R0 of 1 means 100 will infect 1 each = another 100 infected.

But,

2. It could be 1 person infecting 100 person while 99 dont.

Both are R0 =1 , but implications are different.
And from what we observe, situation 2 (or similar) is more likely than 1. It’s almost always a super spreader event/location or environments like close, crowded areas which becomes a cluster & spreads.

This is why factory clusters will seed the infection elsewhere.
That is why we need to backward trace, to find source of infection which lead to = clusters. Forward tracing will give u the R0, but b/ward tracing will give u the K, dispersion factor, which we know is more important to assess spread.

But b/ward tracing is resource intensive.
Point is, if u want to find the source of infection, look for dispersion factor. If u know where are your super spreader events/locations, u can deploy better/targeted PH measures.

Because that’s how C19 spreads.
Relying on R0/Rt to implement lockdowns wont close the spread fast enough. U dont use a number based on the average potential transmissibility to stop spread. Unless u lockdown forever. Which we know what are the costs.

/end.

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More from @yoongkhean

1 Jun
I still see ppl claiming having vaccine side effects or reactions is a sign of the vaccine ‘working’. This is false, please do not cause unnecessary worry to those who did not experience any side effects.

Let me try & explain. /continue
The immune system respond to the vaccine (or any foreign pathogen) by 2 ways.

1. Innate immunity: this is the initial response where all the white cells come out & play, trying to clear the body from the foreign particles. The physical manifestations r fever, body ache etc.
The innate immunity response is not a measure of how hard the body is working or building antibodies. And can be addicted by various factors: age, gender, co-morbids, stress, lack of sleep, hormones. List goes on.
Read 8 tweets
31 May
Govt not wasting the school holidays. Kids >12 years old can to register for vaccination tmrw onwards. Adults <40 to start mid June.
Removing barriers is important to achieve high uptake. System should always be optimised to cater to the least privileged.
A lot of talk on vaccines but this is probably the most significant shift in mindset. Easy DIY test kits available any time at pharmacies for public to self test.

Seems to me govt accepting virus will be in the community, like an endemic & possibility of small outbreaks.
Read 4 tweets
29 May
Had a couple of days to think about the option of choosing vaccines in the mainstream PICK, so here are my thoughts:

These tweets are not really about whether it is a right decision but more of a ‘why’ & ‘how’ about it. Whether it is the right call, I think only time can tell.
Vaccine preference, whether we want to admit, do play a part in vaccine uptake. We always assume all who want to get vaccinated wont mind which type we get, but that’s not entirely true. I wrote about it little here:

medium.com/@Yoongkhean/co…
The theory of letting folks choose their vaccines is to cover whatever hesitancy, valid or invalid, people might have & subsequently increase uptake.

But the viability of that system hinges on 3 factors:\

1. Availability
2. Accessibility
3. Equitability
Read 9 tweets
2 May
Been answering Qs for the most part of the day, found out some misconception re: AZ vaccine or C19 vaccines in general. Would like to address these concerns/misconception.

Just to give everyone more in depth information that could help u understand more.
1. Blood disorders e.g Thalassemia, G6PD deficiency.

In general, this group mostly have no problems w receiving the vaccine. Even Haemophilia, platelet function disorders. Only consideration is if u are on treatment for these diseases, then u should consult your doctor.
2. On blood thinners.

Those on drugs like Warfarin, Aspirin, Dabigatran etc, all can take the vaccine safely. The concern is not increasing the AZ clot risk, the concern w blood thinners is after getting the shot, your arm bleeds intramuscularly.
Read 9 tweets
1 May
Not going to repeat the ultra low incidence of blood clots in the AZ vaccines, think we’ve established that the benefits far outweigh the risks now.

But since tmrw is the big day, would like to offer some thoughts on other data, re: risk factors for the clots.
Most news sites will mention incidence is higher in younger age group & mostly women. However, European regulators does not mention this two groups are a risk factor, merely ‘incidence occurring higher in this 2 groups’.

Why?
1. Data is still in flux. Vaccination programs with AZ is ongoing & because of the phased nature i.e roll out in different age groups, occupation etc, means we don’t have a full set of data yet. Basically, the data is uneven.
Read 8 tweets
1 May
I’m all for getting jabs in to arms & highly recommend everyone to get any approved vaccine but funnelling all the traffic to 1 website for 260k shots will be messy.

Building a system to vaccinate the whole country is a very complicated task but there has to be a simpler way.
Some initial thoughts re: this parallel AZ track is how about those w/out internet/smartphone/laptop access?

While trying to increase no. of ppl vaccinated is the ultimate goal, the system cannot widen the inequity gap further.
Selangor/KL is highly dense & urbanised, probably why they decided to open it up there first, but doesnt address the equally wide inequality gap there.

Migrant workers, B40s, marginalised groups, etc. These groups can jostle with the rest of the M40s & above to book their appts.
Read 7 tweets

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