Thread by @TimothyChase

@lalani_safina @maudi_ahmed @AntibioticDoc (1/n) There is going to be done variation in immune response among people who are fully vaccinated. Some people will have a stronger, more effective response than others, older people will tend to see their protection wane more quickly.

@lalani_safina @maudi_ahmed @AntibioticDoc (2/n) Although the numbers are small, breakthrough infections in Israel are happening more often among those first vaccinated, at the six month mark, but is this because the vaccines are wearing off due to it being six months or that older people were vaccinated first - or both?

@lalani_safina @maudi_ahmed @AntibioticDoc (3/n) Difficult to say at this point. But that kind of variation, while troubling, isn't as dangerous as a mix of vaccinated and unvaccinated. everyone is vaccinated, there may be some transmission, but chains of transmission will tend to burn themselves out.

@lalani_safina @maudi_ahmed @AntibioticDoc (4/n) But with the mix, the virus had the chance to be exposed to antibodies in weakened subjects, then create multiple chains of infection in the unvaccinated, then infect more people who have been vaccinated but are having a weaker response. Each time it infects someone...

@lalani_safina @maudi_ahmed @AntibioticDoc (5/n) who had a weaker immune response the virus is able to acquire a greater degree of Immune escape and the immunity conferred by being vaccinated is generally more degraded.

@lalani_safina @maudi_ahmed @AntibioticDoc (6/n) And unfortunately those who are only partially vaccinated in virtue of having had only one shot of a two shot vaccine simply accelerate the process. Furthermore, you can receive two shots and still not be fully vaccinated. It takes two weeks after the second shot...

@lalani_safina @maudi_ahmed @AntibioticDoc (7/7) before one achieves peak immunity. We need to get those second shots into arms before the wave really begins to build. Especially with Delta as it shows little reaction to a single shot of a two shot vaccine.