8 major changes initiated by the mitochondria to combat viruses, bacteria, & chemical toxins.
Consistent CDR expression results in chronic cellular inflammation, leading to long-term disease.
The CDR is a set of changes made in the cell, controlled & initiated by the mitochondria, that serve to protect the cell from threat/stress/injury/infection & signal a warning to neighboring cells.
The mitochondria has its own DNA which encodes about 1300 proteins to help it carry out its many functions; one of those being the ability to sense a disturbance in electron flow & sulfur oxidation.
Here I will go over:
⁃DNA Pol Eta (translesion synthesis)
⁃Nucleotide Excision Repair
These are two mechanisms that work proficiently to prevent skin cancer, & are part of why I believe the sun does not cause it.
UV rays can cause a wide variety of damage to DNA. They most commonly break the backbone of DNA which causes single & double stranded breaks.
They can also cause thymine dimers:
Thymine dimers are when two thymines that are next to each other on a strand get covalently bonded together, which contorts them into a shape where they are not able to form H-bonds with their base pair.