Cell Danger Response (CDR)
8 major changes initiated by the mitochondria to combat viruses, bacteria, & chemical toxins.
Consistent CDR expression results in chronic cellular inflammation, leading to long-term disease.
8 major changes initiated by the mitochondria to combat viruses, bacteria, & chemical toxins.
Consistent CDR expression results in chronic cellular inflammation, leading to long-term disease.
The CDR is a set of changes made in the cell, controlled & initiated by the mitochondria, that serve to protect the cell from threat/stress/injury/infection & signal a warning to neighboring cells.
The mitochondria has its own DNA which encodes about 1300 proteins to help it carry out its many functions; one of those being the ability to sense a disturbance in electron flow & sulfur oxidation.
Upon detecting a disturbance, the mitochondria will immediately slow its consumption of oxygen, creating an oxygen surplus in the cell to stop an infecting virus from making its own polymers.
The CDR is essential for mounting a defense against an infecting virus or bacteria.
The CDR is essential for mounting a defense against an infecting virus or bacteria.
Why does this matter?
The CDR is ancient & essential.
It evolved to respond to viral, bacterial, & physical stressors that are common in the environment.
However, it can be initiated by anything that disturbs electron flow & sulfur oxidation in the cell.
The CDR is ancient & essential.
It evolved to respond to viral, bacterial, & physical stressors that are common in the environment.
However, it can be initiated by anything that disturbs electron flow & sulfur oxidation in the cell.
Industrial chemicals, drugs, dyes, & pesticides (etc) can initiate CDR, & being coupled with bio threats can increase the intensity of the response.
Not only this, but the constant exposure to environmental toxins can keep cells in a constant state of alarm & altered metabolism
Not only this, but the constant exposure to environmental toxins can keep cells in a constant state of alarm & altered metabolism
Here are the 8 major changes that the CDR activates in the cell.
1.Shifts cell metabolism from net synthesis to monomer synthesis to prevent hijacking from pathogens.
2.Stiffens membranes to limit pathogen egress.
1.Shifts cell metabolism from net synthesis to monomer synthesis to prevent hijacking from pathogens.
2.Stiffens membranes to limit pathogen egress.
3.Releases anti microbial & antiviral chemicals in & around the cell.
4.Increases autophagy & mitochondrial fission to remove intercellular pathogens.
5.Changes DNA methylation & histone modification to alter gene expression.
4.Increases autophagy & mitochondrial fission to remove intercellular pathogens.
5.Changes DNA methylation & histone modification to alter gene expression.
6.Produces genetic variations with endogenous retroviruses & transposons.
7.Warns neighboring cells & effector cells of danger.
8.Alters the behavior & sleep pattern of the host to facilitate healing & prevent spread to kin.
7.Warns neighboring cells & effector cells of danger.
8.Alters the behavior & sleep pattern of the host to facilitate healing & prevent spread to kin.
A last thought to leave you with:
Modern day environmental chemicals & toxins have the ability to initiate this response. Exposure to thousands of them each day is almost unavoidable.
Modern day environmental chemicals & toxins have the ability to initiate this response. Exposure to thousands of them each day is almost unavoidable.
Chronic CDR expression has been linked with many chronic diseases & disorders which stem from chronic cellular inflammation.
It is likely that everyone is experiencing cellular inflammation due to CDR at some magnitude whether it be large or small.
It is likely that everyone is experiencing cellular inflammation due to CDR at some magnitude whether it be large or small.
I plan on tweeting more about this in the coming months as I expand my own knowledge on each of the 8 changes.
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