[Thread] Necessary corrections to the China-WHO report.
What they will probably fix and what they will not.
TLDR: circular swap of 3 IPCAMS genomes + tampered onset of Wuchang accountant; First patients and first cluster; Some falsehoods in articles washingtonpost.com/world/asia_pac…
As we said, the problems were with S01, S05 & S11. Absolutely chaotic, but with a little table it is all more clear. Part of the problem is inherited from Ren et al. (2020) who followed different orders in the text and in the genomes for the patients.
The Wuchang accountant and nephew of a doctor of the hospital (Central) was probably a most convenient 1st case, and Lineage B!
(Image from China-WHO report annex D1 - Xinhua Hospital)
Holmes et al. (2021) also found something was wrong with S01. Although they did not solve the whole jigsaw puzzle (as part of their cherry picking, I guess)
How can they change now the info of the wife of the 62-year-old man (62M) stated in the China WHO-report? Incredible!
62M (some sources said "in his seventies" or "elderly") had that initial onset on Dec 1st (Huang et al., 2020).
But seems that Huang et al. (2020) hid the h2h evidence, if we trust China-WHO report and Xinhuanet. @TheLancet please clarify/correct/retract. ncbi.nlm.nih.gov/pmc/articles/P…
Thanks to them, Dr. Jixian Zhang alerted of very probable h2h on Dec 27th. But we only knew that -and limited- on Jan 20th, 24 days later.
Shame! xinhuanet.com/english/2020-0…
62M is also "ICU-01" in Zhou et al. (2020) whose "contact history [with wet market] is unclear"
Why nothing was sequenced? Did they sequenced the wife? Who is the wife? 49F or one of the 3 ICU patients omitted by Zhou et al. (2020)? nature.com/articles/s4158… nature.com/articles/s4158…
From the WaPo article:
"Jasarevic said mistakes in the report were due to “editing errors,” but they did not affect “the data analysis process, nor the conclusions.”"
No comments!
🧵Natural and non-natural live isolates (WIV & related)
TLDR:
- A substantial portion of the research remains unpublished.
- Missing live isolate WIV15.
- No samples, isolates, chimeric and MA viruses in 2017-2019?
- What is "Rs4874" really?
https://t.co/9JPusWbl9l
First, it is very important to distinguish between a sequence and an isolated virus. Isolating a virus is very difficult. The ratio is perhaps one in hundreds sequenced. WIV has obtained thousands of virus sequences but only a few live viruses.
Misc:
- Rambaut now more involved (added to "Software" and "Data curation" in the contributions).
- The 155 cases turned now into 156 cases.
- Fig 1E then vs now (they forgot to update Fig 2B too).
- Fig 1A: many cases shifted East hundreds of m.
Judge yourself. They were looking for new SARS viruses different from SARS1 but this one found investigating a COVID-like outbreak in miners was not interesting and they made a mistake saying the miners had SARS antibodies.
Las declaraciones del Dr. Joan-Ramon Laporte Roselló (catedrático Farmacología, CV impresionante y sin COIs) en el Congreso, convocado por Podemos y PSOE, no han sentado nada bien. Le están tachando de "negacionista" sin refutar nada de lo que dice
1/n
[48:25] Hay que vacunar a inmunodeprimidos, pero en niños y adolescentes puede ser contraproducente. La mayoría de los menores de 20 que han fallecido por COVID tenían enfermedades graves. Hay que huir de recetas oficiales y pensar críticamente. "Lo primero es no hacer daño" 2/n
[52:06] En los ensayos clínicos no se vio claro que vacunas salvaran vidas. Los datos epidemiológicos muestran que nos salvan de hospitalizaciones, pero no nos salvan de la transmisión. No debería contar para un certificado COVID.