i was prepared for some potential bad takes when i opened nature.com/articles/d4158… but last 2 paragraphs just blew me the fuck away.
let's start with, uh, how little empathy do you have to have to write the words "more death, although seriously concerning, is a minor problem..."?
let's start with, uh, how little empathy do you have to have to write the words "more death, although seriously concerning, is a minor problem..."?
anyway i seriously am blown away that this person is a virologist. i thought that we moved past the whole "partial immunity" nonsense an eternity ago.
you can select for escape mutants towards a monoclonal or an antiviral. b/c those can't fucking ADAPT to the virus.
you can select for escape mutants towards a monoclonal or an antiviral. b/c those can't fucking ADAPT to the virus.
guess what our adaptive immune system can do, OTOH? this is assuming it manages to escape a complex polyclonal response over multiple arms of the adaptive immune system.
this. just. isn't. how. it. works.
for starters, let's just take the most obvious thing: immunity from natural infection seems comparable to 1-dose mRNA vax. but in that case the two are not meaningfully different to a virus from an antigenic evolution PoV.
for starters, let's just take the most obvious thing: immunity from natural infection seems comparable to 1-dose mRNA vax. but in that case the two are not meaningfully different to a virus from an antigenic evolution PoV.
secondly, CoV antigenic drift is capable of giving us a virus capable of evading sterilizing immunity & giving us a nasty cold for a few days. this is not the same as an immunologically novel virus.
there's a reason HCoV-OC43 pneumonia cases are extremely rare & it's b/c everyone has their first infection in early childhood (various papers i've read place median age of first infection between 5 - 7 years old).
i am now increasingly confident this will be the case too for #SARSCoV2 in a vaccinated individual for, again, all but the rarest of immunocompetent cases.
people somehow seem to keep forgetting that T cells exist & it's so exhausting.
people somehow seem to keep forgetting that T cells exist & it's so exhausting.
like, i just don't get it. why do people seem to keep forgetting *basic* immunology while making extremely confident answers to virus evolution questions that we can't even answer for something like measles?
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