1/ Today, Pfizer released a PRE-PRINT with 6 months of follow-up data for its phase 2/3 COVID vaccine trial: medrxiv.org/content/10.110…
THE TAKEAWAY: 2 doses of the Pfizer vaccine are highly effective in preventing severe disease, hospitalization, & death out to 6 months.
2/ Pfizer saw no new safety issues between its 2-month and 6-month analyses.
This is consistent with what we've seen with every other vaccine. If people are going to have a side-effect from a vaccine, they'll have it within 2 months of getting vaccinated.
3/ The Pfizer vaccine was over highly effective in preventing ANY SYMPTOMATIC INFECTION out to 6 months:
2 months 96% 2-4 months 90% 4-6 months 84%
4/ Vaccine efficacy against severe disease and death were in the mid-high 90% out to at least 6 months.
Vaccine efficacy for severe COVID disease in South Africa was 100%. The Beta variant, which is the MOST immune-evading of the variants, is prevalent in South Africa.
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1/ This latest paper by @KizzyPhD, who helped develop @moderna_tx's mRNA COVID vaccine, helps us understand why vaccines can protect against severe disease in the lungs but not mild infection in the nose and throat. science.sciencemag.org/content/early/…
2/ Lower antibody levels are needed for reduction of viral replication in the lower airway than in the upper airway.
RNA in BAL = amount of virus in the lungs drops more quickly than
RNA nasal swabs (NS) = amount of virus in the upper airway
3/ Antibodies taken from unvaccinated & vaccinated non-human primates (NHPs) were infused into hamsters.
Hamsters that were given antibodies from NHP who received the higher dose vaccine had little/no weight loss (i.e. little/no disease).
1/ Clearing up confusion about what it means that Delta viral loads are ~1000x higher than the viral loads seen with the original SARS-CoV-2. medpagetoday.com/special-report…
2/ We need to be precise in speaking about infectiousness.
Exposure = Dose x Time
If viral loads in infected people are ~1000x higher with Delta than original SARS-CoV-2, the dose of virus to which the uninfected person is exposed has gone up ~1000x.
3/ Exposure = Dose x Time
If Dose increases 1000x
the Exposure you would have gotten from an infected person early in the pandemic over 15 minutes
you now get in 0.9 seconds (~1 second).
15 minutes = 900 seconds
But in NEITHER scenario are you 100% sure to be infected.
2/ COVID VACCINES WORK. They protect you from severe disease, hospitalization, and death.
IF YOU HAVEN'T YET GOTTEN VACCINATED, THIS IS THE TIME.
3/ The Delta variant has turned suburban streets into a @NASCAR track.
Seatbelts might be enough to keep you safe when you're driving in your suburban neighborhood, but if you're a NASCAR driver, you also want a helmet, airbags, and more.