I hope real experts in EBM know that the idea cloth masks "work" on vaccinated people with >50/100k cases SUMMED over 7 days with delta, but not pre-delta, & not at lower case rates, is actually....

100% MADE UP
Like, I hope that masks have not been so politicized and so linked to virtue that the last intelligent person in biomedicine actually thinks this is evidence based anything
Instead, what it is is the APPEARANCE of doing something, as we wait for the inevitable break in the pandemic trajectory
Since no one actually did any cluster RCTs of masks, because experts in EBM were too busy recommending stuffing panty liner in masks, we actually know next to nothing
Next to nothing about
Which masks work
N95, surgical, cloth

How mandates work

If it interacts by
age
rate of spread in community
duration of times in closed indoor space
size of venue (cubic feet of air)
etc
Good think reductionist science, which has failed spectacularly in biomedicine, was used to "prove" cloth masks work even in vaccinated people

😂😂

Maybe someday the 4 people left who know better will speak up

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More from @VPrasadMDMPH

1 Aug
Crossed the 300 peer review publication mark recently #nomedicalwriters

Here is what I learned over 12 years of publishing

1. Don't include too many authors...
You have to type their name, affiliation AND email into those damn submission portals
God help 30+ collaborators! Image
2. Well, if someone is willing to submit the paper, maybe they do deserve to be a co-author after all
#letsnotbehasty
3. If the journal asks you to suggest reviewers, you will probably suggest people you think will like the paper or people who like you
#nohaters
Read 26 tweets
31 Jul
The idea that Delta somehow changes the risk benefit for kids attending school is literally the dumbest idea I've heard

Unless a new variant has an IFR 10-fold higher in that age group, the net benefit is to continue school in person

School has mental and physical benefits
It has benefits on upward mobility, socioeconomic status, equality, civics, society.
It was always a bad idea to close schools. It was a forgivable bad idea in the spring of 2020. By the fall of 2020, the data were clear and it was no longer a forgivable mistake. By 2021 It's criminal to keep it closed any longer
Read 7 tweets
29 Jul
I appreciate this thread by @SarahKarlin an excellent biotech/ regulatory reporter

Some thoughts on Pazdur's comments [thread]
First, all this fiasco is due to Rick himself!
STAT reports that he advised FDA to approve aduhelm by AA, which drew attention to the pathway

The pathway had been abused for years in cancer, but few cared; now all eyes on it.

He has only himself to blame for the attention!!
Next, as background. FDA lets cancer drugs come to market that improve survival AND some that shrink tumors (RR) or slow their growth past arbitrary thresholds (PFS)

The ratio is what, would you guess?
5:1?
4:1?
....
Read 15 tweets

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