There's a lot to dig in here but a few things that jump out about Delta particularly:
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Delta objectively spreads faster than the original COVID strain. The original strain was less transmissible than polio & smallpox; Delta is more transmissible than those as well as Ebola, MERS, SARS, & the Spanish Flu.
Delta is *as* transmissible as chicken pox.
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Delta is associated with a higher viral load and longer duration of shedding.
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A big one: breakthrough cases from Delta may be as transmissible as unvaccinated cases.
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Data suggesting that Delta may cause more severe disease.
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Some preliminary data show that the vaccines may be less protective against non-hospitalized symptomatic infections of Delta. (This is bad news & will likely mean more #LongCOVID cases.)
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From the CDC's model, Delta cannot be controlled without universal masking!
This seems to be where their change in policy is coming from.
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Finally, a list of much needed changes to public communication from the CDC, including to "acknowledge the war has changed". Delta is different & concerning, and vaccinated individuals still are at risk.
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In short: we are not through the woods, and the CDC's de-masking recommendations came too early.
Everyone should return to masking & should be aware that being vaccinated can't be the sole means of protection on its own, but instead used alongside other precautions.
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Vaccinated individuals are less likely to be hospitalized & die, but with Delta they risk transmitting COVID to others, including unvaccinated kids (who seem to be at greater risk from Delta).
They also remain at risk of contracting #LongCOVID from breakthrough infections.
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This could cause additional impacts like deficits in platelet energy metabolism, or hormonal dysregulation (because platelets carry serotonin) #LongCovid
Because this video has caused so much willful misinterpretation, I want to clarify: in the clip I’m countering the myth that #longcovid is lingering symptoms of acute COVID, since many people think it’s just a cough. I should‘ve said “acute COVID”; brain fogged & trying my best.
The interview was an hour long & they edited it to 5 min. I talked their ear off about all hypotheses & the science behind each & it didn’t make it in - the piece was for a general audience. I talked about all the other things COVID can cause, include diabetes & clots, at length.
Anyone who is suggesting I don’t think #longcovid is from COVID (????) or that I don’t think viral persistence is a high priority hypothesis (????) are *actively* ignoring 3.5 yrs of advocacy & that I’ve been highlighting viral persistence since 2020
The most exciting hypotheses in #LongCovid and #pwME are ones that could have cures! This includes viral persistence and others, and also includes the itaconate shunt hypothesis. I'm going to tweet this video as I watch it to try to explain it more 1/
Dr. Ron Davis used to work on the Human Genome Project but switched to ME/CFS when his son got sick. He's the director at the Stanford Genome Center. He is focused on *a cure* for ME/CFS. "I believe it is a curable disease." 2/
He describes the common onsets of ME - usually viral, but can have other causes too, refers to a big parasite onset in Norway from a few years ago 3/
@TheCrankyQueer: highlight the need for trans inclusion in trials, including understanding how different labs may present; biomarker nuance
Oved Amitay: need to create a center of excellence to learn from trials in other diseases 1/
Oved: FDA needs to align on decisions across similar fields, needs cross-talk across similar groups
@Dysautonomia: Most even great researchers don't understand autonomic disorders, which happen in up to 2/3 of LC...is there an opportunity to offer autonomic training? 2/
@Dysautonomia: Also, need to make arms in these trials for pre-Covid POTS/MECFS - this helps learn about LC as well (ie does Paxlovid help pre-covid pts)
"Fatigue turns the most mundane of tasks into an “agonizing cost-benefit analysis,” @turnoftheshrew said. If you do laundry, how long will you need to rest to later make a meal? If you drink water, will you be able to reach the toilet?"
2/
"Only a quarter of long-haulers have symptoms that severely limit their daily activities, but even those with “moderate” cases are profoundly limited. @julialmv still works, but washing her hair, she told me, leaves her as exhausted as the long-distance runs she used to do." 3/
Other factors that correlated with INCREASED likelihood to recover from #LongCovid include:
-being male
-having cardiovascular comorbidities
-lost appetite in acute phase
-had smell/taste alterations (this is often its own subtype that can come with no other symptoms)
3/