There's a lot to dig in here but a few things that jump out about Delta particularly:
1/
Delta objectively spreads faster than the original COVID strain. The original strain was less transmissible than polio & smallpox; Delta is more transmissible than those as well as Ebola, MERS, SARS, & the Spanish Flu.
Delta is *as* transmissible as chicken pox.
2/
Delta is associated with a higher viral load and longer duration of shedding.
3/
A big one: breakthrough cases from Delta may be as transmissible as unvaccinated cases.
4/
Data suggesting that Delta may cause more severe disease.
5/
Some preliminary data show that the vaccines may be less protective against non-hospitalized symptomatic infections of Delta. (This is bad news & will likely mean more #LongCOVID cases.)
6/
From the CDC's model, Delta cannot be controlled without universal masking!
This seems to be where their change in policy is coming from.
7/
Finally, a list of much needed changes to public communication from the CDC, including to "acknowledge the war has changed". Delta is different & concerning, and vaccinated individuals still are at risk.
8/
In short: we are not through the woods, and the CDC's de-masking recommendations came too early.
Everyone should return to masking & should be aware that being vaccinated can't be the sole means of protection on its own, but instead used alongside other precautions.
9/
Vaccinated individuals are less likely to be hospitalized & die, but with Delta they risk transmitting COVID to others, including unvaccinated kids (who seem to be at greater risk from Delta).
They also remain at risk of contracting #LongCOVID from breakthrough infections.
10/
44 countries have experienced a 10-fold increase in at least 13 infectious diseases compared to pre-pandemic rates, including RSV, cholera, measles, influenza, chickenpox, tuberculosis (TB), and others. 2/
While some (like TB) may be related to declining vaccination rates, COVID impacts the others.
"Immune mechanisms [like] a period of increased vulnerability to other infections following acute COVID infection" is a major contributor, esp irt respiratory infections in children 3/
Michael Peluso (@MichaelPelusoMD) introduces CHIIME, which adds an arm of ME/CFS patients to the LIINC study - will include PET imaging and tissue biopsy analysis, gut biopsies:
Phenotyping with patient-reported and objective clinical measures:
Incredible visit Thursday to the opening of Mount Sinai’s Cohen Center for Recovery from Complex Chronic Illness, led by the renowned @PutrinoLab! #LongCovid 1/
The Center is incredible and truly blew me away - designed on so many levels with patients in mind, with top notch care, using many of the most advanced tools available 2/
Some of the many tools patients are assessed with include:
The fibrin also:
-promotes neuroinflammation & neuronal loss post infection
-promotes innate immune activation in the brain & lungs independent of active infection
-downregulated JAK-STAT pathway & targets of p38 MAP kinase, pathways that regulate NK cell activation #LongCovid 2/
They used a monoclonal antibody targeting the fibrin domain, and found it protected against microglial activation & neuronal injury, as well as from thromboinflammation in the lung after infection! #LongCovid 3/
I've been doing #TheNicotineTest (via 7mg patches) for a month now & it has greatly improved my quality of life.
Major caveat: I'm on ivabradine. The nicotine increases heart rate, & I wouldn't recommend to anyone w POTS who isn't on beta-blockers or ivabradine. #LongCovid 1/
The biggest change is feeling like I have more *oxygen* circulating in my body - the weird altitude-sickness feeling is lessened.
Major improvements to cognition/awareness (esp executive functioning & processing), and improved physical capacity and overall baseline. 2/
The first tolerance break I felt more air hunger and worse baseline than pre-nicotine, but every other tolerance break has been equal or better than pre-nicotine.
It feels like an excellent symptom management tool, but *not* a cure. 3/
This could cause additional impacts like deficits in platelet energy metabolism, or hormonal dysregulation (because platelets carry serotonin) #LongCovid