Hannah Davis Profile picture
Jul 30, 2021 11 tweets 4 min read Read on X
This seems to be the leaked data the CDC used to change the mask mandate this week:

context-cdn.washingtonpost.com/notes/prod/def…

There's a lot to dig in here but a few things that jump out about Delta particularly:

1/
Delta objectively spreads faster than the original COVID strain. The original strain was less transmissible than polio & smallpox; Delta is more transmissible than those as well as Ebola, MERS, SARS, & the Spanish Flu.

Delta is *as* transmissible as chicken pox.

2/
Delta is associated with a higher viral load and longer duration of shedding.

3/
A big one: breakthrough cases from Delta may be as transmissible as unvaccinated cases.

4/
Data suggesting that Delta may cause more severe disease.

5/
Some preliminary data show that the vaccines may be less protective against non-hospitalized symptomatic infections of Delta. (This is bad news & will likely mean more #LongCOVID cases.)

6/
From the CDC's model, Delta cannot be controlled without universal masking!

This seems to be where their change in policy is coming from.

7/
Finally, a list of much needed changes to public communication from the CDC, including to "acknowledge the war has changed". Delta is different & concerning, and vaccinated individuals still are at risk.

8/
In short: we are not through the woods, and the CDC's de-masking recommendations came too early.

Everyone should return to masking & should be aware that being vaccinated can't be the sole means of protection on its own, but instead used alongside other precautions.

9/
Vaccinated individuals are less likely to be hospitalized & die, but with Delta they risk transmitting COVID to others, including unvaccinated kids (who seem to be at greater risk from Delta).

They also remain at risk of contracting #LongCOVID from breakthrough infections.

10/
A very relevant thread to end on:



11/

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More from @ahandvanish

May 1
From the Conference of Retroviruses & Opportunistic Infections: persistence of Covid in megakaryocytes in #LongCovid.

Over my head, but my understanding: megakaryocytes (type of bone marrow cell) being infected = continuous infection, very serious!

1/ croiconference.org/wp-content/upl…
graph showing levels of circulating Megakaryocytes; very low for healthy controls, high for severe Covid and Long Covid
This could cause additional impacts like deficits in platelet energy metabolism, or hormonal dysregulation (because platelets carry serotonin) #LongCovid

More about this here from the amazing @polybioRF!

2/polybio.org/projects/sars-…
The study found:

-circulating megakaryocytes harbored Spike, SARS-CoV-2 ssRNA, & dsRNA in #LongCovid patients

-these produced platelets containing Spike & SARS-CoV-2 ssRNA 3/
Read 5 tweets
Oct 30, 2023
Because this video has caused so much willful misinterpretation, I want to clarify: in the clip I’m countering the myth that #longcovid is lingering symptoms of acute COVID, since many people think it’s just a cough. I should‘ve said “acute COVID”; brain fogged & trying my best.
The interview was an hour long & they edited it to 5 min. I talked their ear off about all hypotheses & the science behind each & it didn’t make it in - the piece was for a general audience. I talked about all the other things COVID can cause, include diabetes & clots, at length.
Anyone who is suggesting I don’t think #longcovid is from COVID (????) or that I don’t think viral persistence is a high priority hypothesis (????) are *actively* ignoring 3.5 yrs of advocacy & that I’ve been highlighting viral persistence since 2020
Read 7 tweets
Sep 20, 2023
The most exciting hypotheses in #LongCovid and #pwME are ones that could have cures! This includes viral persistence and others, and also includes the itaconate shunt hypothesis. I'm going to tweet this video as I watch it to try to explain it more 1/
Dr. Ron Davis used to work on the Human Genome Project but switched to ME/CFS when his son got sick. He's the director at the Stanford Genome Center. He is focused on *a cure* for ME/CFS. "I believe it is a curable disease." 2/ slide that says "ME/CFS - A curable disease?"
He describes the common onsets of ME - usually viral, but can have other causes too, refers to a big parasite onset in Norway from a few years ago 3/ Image
Read 13 tweets
Sep 11, 2023
FDA Stakeholder meeting on #LongCovid today:

@TheCrankyQueer: highlight the need for trans inclusion in trials, including understanding how different labs may present; biomarker nuance

Oved Amitay: need to create a center of excellence to learn from trials in other diseases 1/
Oved: FDA needs to align on decisions across similar fields, needs cross-talk across similar groups

@Dysautonomia: Most even great researchers don't understand autonomic disorders, which happen in up to 2/3 of LC...is there an opportunity to offer autonomic training? 2/
@Dysautonomia: Also, need to make arms in these trials for pre-Covid POTS/MECFS - this helps learn about LC as well (ie does Paxlovid help pre-covid pts)

Me: There are over 50 drugs ready to be trialed: 3/docs.google.com/document/d/1JJ…
Read 24 tweets
Jul 27, 2023
A beautiful piece by @edyong209 that fully describes & communicates the complexity of fatigue & Post-Exertional Malaise in #LongCovid.

Ironically am crashy today so going to pull out amazing quotes:

"Now, at least, she can watch TV on the same day she takes a shower." 1/
"Fatigue turns the most mundane of tasks into an “agonizing cost-benefit analysis,” @turnoftheshrew said. If you do laundry, how long will you need to rest to later make a meal? If you drink water, will you be able to reach the toilet?"

2/
"Only a quarter of long-haulers have symptoms that severely limit their daily activities, but even those with “moderate” cases are profoundly limited. @julialmv still works, but washing her hair, she told me, leaves her as exhausted as the long-distance runs she used to do." 3/
Read 33 tweets
Jul 13, 2023
This is one of the most accurate papers on #LongCovid recovery I've seen. It's full of crucial points:

-Only 7.6% recovered.

-Recovery was *more* likely in people who were in the ICU. This was something we saw early, but why?

A few thoughts:

1/ https://t.co/kdPhkTVR5mpapers.ssrn.com/sol3/papers.cf…
Those hospitalized with COVID, esp in the early pandemic, seem more likely to have forms of #LongCovid that are *not* the neurological form.

The neuro form seems to last longer (& often overlaps with ME/CFS & dysautonomia, lifelong conditions).



2/
Other factors that correlated with INCREASED likelihood to recover from #LongCovid include:

-being male
-having cardiovascular comorbidities
-lost appetite in acute phase
-had smell/taste alterations (this is often its own subtype that can come with no other symptoms)

3/
Read 10 tweets

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