COVID19:
Good news for (mostly) all!
Progress continues on development of polyclonal antibodies, a key in early and effective treatments, possibly preventative prophylaxis.
BAD news for me. None of these will help me....
Good news for (mostly) all!
Progress continues on development of polyclonal antibodies, a key in early and effective treatments, possibly preventative prophylaxis.
BAD news for me. None of these will help me....
First, an article discussing development of antibodies sourced from equines...
thelancet.com/journals/eclin…
thelancet.com/journals/eclin…
Second, another rapidly progressing development of polyclonal antibodies.
From llamas.
news-medical.net/amp/news/20210…
From llamas.
news-medical.net/amp/news/20210…
Is it all BAD NEWS for us poor saps with #alphagal?
No. There's some light.
As a reminder, it was only LAST YEAR, that FDA approved the GAL-safe pig for medical use AND human consumption.
Ummm. Bacon...Ribs...Ham...coming my way soon...🤩🤩🤩
fda.gov/news-events/pr…
No. There's some light.
As a reminder, it was only LAST YEAR, that FDA approved the GAL-safe pig for medical use AND human consumption.
Ummm. Bacon...Ribs...Ham...coming my way soon...🤩🤩🤩
fda.gov/news-events/pr…
At least one group of COVID researchers kept us in their consideration.
I present...gal-safe COVID polyclonal antibodies.
I hope Nurse Ratchet saves these for me when I hit her ER.
biorxiv.org/content/10.110…
I present...gal-safe COVID polyclonal antibodies.
I hope Nurse Ratchet saves these for me when I hit her ER.
biorxiv.org/content/10.110…
Honestly?
Just send me the pig.
I'll stay home.
And cook....
Just send me the pig.
I'll stay home.
And cook....
On the vaccine side, there is research on vaccine development that is capable of blocking three-point mutations, and sterilizing immunity (essential for stopping infections, protecting patient, blocking variant creation).
nature.com/articles/d4158…
nature.com/articles/d4158…
One I like, deep in the article:
"Gritstone Oncology decided to focus on this potential problem by designing a vaccine that targets multiple sites on several viral proteins, in contrast to first-generation shots that target only the spike protein..."
"Gritstone Oncology decided to focus on this potential problem by designing a vaccine that targets multiple sites on several viral proteins, in contrast to first-generation shots that target only the spike protein..."
On the vaccine side, there is research on vaccine development that is capable of blocking three-point mutations, and sterilizing immunity (essential for stopping infections, protecting patient, blocking variant creation).
nature.com/articles/d4158…
nature.com/articles/d4158…
Why is this CRITICAL?
"vaccines that do not provide sterilizing immunity (and therefore continue to permit transmission) will lead to the buildup of large standing populations of virus [47], greatly increasing the risk of immune escape."
journals.plos.org/plosone/articl…
"vaccines that do not provide sterilizing immunity (and therefore continue to permit transmission) will lead to the buildup of large standing populations of virus [47], greatly increasing the risk of immune escape."
journals.plos.org/plosone/articl…
And worse?
"immune evasion requiring one to two mutations occurs within months, raising prospect that phenomenon will further shorten duration of natural immunity, which is already limited by relatively short duration of humoral and cellular responses to SARS-CoV-2 infection."
"immune evasion requiring one to two mutations occurs within months, raising prospect that phenomenon will further shorten duration of natural immunity, which is already limited by relatively short duration of humoral and cellular responses to SARS-CoV-2 infection."
"strategies to prevent SARS-CoV-2 transmission that exert specific pressure on other proteins, or that do not exert a specific selective pressure on the virus are key to reducing the risk of immune escape."
Our vaccines focused ONLY on spike protein.
RECIPE for viral escape!
Our vaccines focused ONLY on spike protein.
RECIPE for viral escape!
One vaccine isn't going to do the job.
Neither is natural immunity!
"we may be condemned to chasing after the evolving SARS-CoV-2 continually, as we have long done for influenza virus...”
cuimc.columbia.edu/news/new-study…
Neither is natural immunity!
"we may be condemned to chasing after the evolving SARS-CoV-2 continually, as we have long done for influenza virus...”
cuimc.columbia.edu/news/new-study…
"Our study and new clinical trial data show that virus is traveling in a direction that is causing it to escape from current vaccines and therapies that are directed against the viral spike...”
But, can we chase this Dragon with more boosters, that still target spike protein?
But, can we chase this Dragon with more boosters, that still target spike protein?
Can we create boosters faster than mutations nullifying them?
Worse, have we created original antigenic sin?
"concerns stem from a phenomenon that is known as imprinting, sometimes called original antigenic sin, which is believed to affect how we respond to some pathogens."
Worse, have we created original antigenic sin?
"concerns stem from a phenomenon that is known as imprinting, sometimes called original antigenic sin, which is believed to affect how we respond to some pathogens."
Imprinting may cause boosters with spike protein variants, to fail in creating unique antibodies.
"encounter sets your immune system’s definition of that virus and what immune weapons it needs to detect and protect against it in the future."
statnews.com/2021/04/16/nex…
"encounter sets your immune system’s definition of that virus and what immune weapons it needs to detect and protect against it in the future."
statnews.com/2021/04/16/nex…
I don't address risk of vaccines, sadly that information is lacking for many reasons, one side exaggerates it another side hides it.
Nor do I suggest avoiding vaccines!
But I do suggest more activism, accelerated development of more aggressive, and mutation-resistant options!
Nor do I suggest avoiding vaccines!
But I do suggest more activism, accelerated development of more aggressive, and mutation-resistant options!
Will our boosters keep up? Will original antigenic sin make them ineffective?
Will it get deadlier?
"we have to be aware that COVID-19 has not thrown its last surprise at us — there will be several more over the next period.”
Don't toss your masks!
pharmaceutical-journal.com/article/news/p…
Will it get deadlier?
"we have to be aware that COVID-19 has not thrown its last surprise at us — there will be several more over the next period.”
Don't toss your masks!
pharmaceutical-journal.com/article/news/p…
A dose of reality in regards to keeping up!
"And as Covid-19 has continued to mutate faster than originally expected — most recently with the rapid spread of the Delta variant, first identified in India — interest in their work has increased."
google.com/amp/s/amp.ft.c…
"And as Covid-19 has continued to mutate faster than originally expected — most recently with the rapid spread of the Delta variant, first identified in India — interest in their work has increased."
google.com/amp/s/amp.ft.c…
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