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'fatbiker on a trike

@urbanfatbiker

30 Jul

COVID19:

Good news for (mostly) all!

Progress continues on development of polyclonal antibodies, a key in early and effective treatments, possibly preventative prophylaxis.

BAD news for me. None of these will help me....

First, an article discussing development of antibodies sourced from equines...
thelancet.com/journals/eclin…

Second, another rapidly progressing development of polyclonal antibodies.

From llamas.
news-medical.net/amp/news/20210…

Read 20 tweets

'fatbiker on a trike

@urbanfatbiker

10 Apr

@chattyknana

@chattyknana @LindaMDickson3 @headdock @ThomasKlineMD @HR4peopleinpain @process_x @secondchances09 @hope411adcock @Technovore1 @SpicyPurritos @funchefchick @PTSDAdvocate @wittywax1 @eullrich11 @ChadDKollas @Nashkitty66 @Chronic_FLKeys @OpioidHysteria @NitaGhei @russell90367011 @ibdgirl76 @EbCummings1 @docroland @WriterMera @onnaroll66 @bluelilly40 @TheDarkGift_ @StopBadDocs @lockedoutofvenu @Deeenst @Canada_NV @maryann19711 @Vlynx5 @SweetDeals16 @Royalacresrod @soofriends @DebM01279692 @CContrarus @aander1987 @life_is_art___ @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall This seems a well-known secret that opioids modulate T-cell activity.

We only hear it as 'destroys immunity', at addiction dosage, probably does.

At therapeutic levels?
It HELPS.

Your report may be ancedotal.
But it's TRUE, it does MORE than help pain.

jimmunol.org/content/202/1_…

@chattyknana

@chattyknana @LindaMDickson3 @headdock @ThomasKlineMD @HR4peopleinpain @process_x @secondchances09 @hope411adcock @Technovore1 @SpicyPurritos @funchefchick @PTSDAdvocate @wittywax1 @eullrich11 @ChadDKollas @Nashkitty66 @Chronic_FLKeys @OpioidHysteria @NitaGhei @russell90367011 @ibdgirl76 @EbCummings1 @docroland @WriterMera @onnaroll66 @bluelilly40 @TheDarkGift_ @StopBadDocs @lockedoutofvenu @Deeenst @Canada_NV @maryann19711 @Vlynx5 @SweetDeals16 @Royalacresrod @soofriends @DebM01279692 @CContrarus @aander1987 @life_is_art___ @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall My rx was primarily used for inflammation driven by immunity flares. Fatigue brings it on, two days of opioid clears it.

Over that 10-year period, I recorded multiple 'less than zero' viral detection by ultrasensitive assay used only in research.

75 of us put in special trial.

@chattyknana

@chattyknana @LindaMDickson3 @headdock @ThomasKlineMD @HR4peopleinpain @process_x @secondchances09 @hope411adcock @Technovore1 @SpicyPurritos @funchefchick @PTSDAdvocate @wittywax1 @eullrich11 @ChadDKollas @Nashkitty66 @Chronic_FLKeys @OpioidHysteria @NitaGhei @russell90367011 @ibdgirl76 @EbCummings1 @docroland @WriterMera @onnaroll66 @bluelilly40 @TheDarkGift_ @StopBadDocs @lockedoutofvenu @Deeenst @Canada_NV @maryann19711 @Vlynx5 @SweetDeals16 @Royalacresrod @soofriends @DebM01279692 @CContrarus @aander1987 @life_is_art___ @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall And Paul Coelho can kiss my ass, every bit of what I say about my opioid use is quantified, assayed, measured, and pieces of me saved for 10 years!

Did I lie?
Reference the NIH deep freeze sample collections to prove it!

Opioids modulate immune function.
Reduce viral escape.

Read 8 tweets

'fatbiker on a trike

@urbanfatbiker

29 Mar

@headdock

@headdock @Nashkitty66 @Canada_NV @hope411adcock @Chronic_FLKeys @bluelilly40 @Deeenst @ThomasKlineMD @StopBadDocs @HR4peopleinpain @chattyknana @maryann19711 @SpicyPurritos @Vlynx5 @SweetDeals16 @secondchances09 @Royalacresrod @Sarahkirk40 @soofriends @DebM01279692 @onnaroll66 @EbCummings1 @russell90367011 @CContrarus @eullrich11 @aander1987 @life_is_art___ @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall @twebber02 Fentalogues were around, it may be disputable how much, but it was a problem for DEA in 2005, an issue with unexplained deaths in east coast ERs in 1991, a 'new twist in an ongoing crisis' as early as 1981.

That is also history, poorly captured by coroners.

@headdock

@headdock @Nashkitty66 @Canada_NV @hope411adcock @Chronic_FLKeys @bluelilly40 @Deeenst @ThomasKlineMD @StopBadDocs @HR4peopleinpain @chattyknana @maryann19711 @SpicyPurritos @Vlynx5 @SweetDeals16 @secondchances09 @Royalacresrod @Sarahkirk40 @soofriends @DebM01279692 @onnaroll66 @EbCummings1 @russell90367011 @CContrarus @eullrich11 @aander1987 @life_is_art___ @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall @twebber02 There are reports of fentalogues in heroin going back as far as 1976.

Heroin itself became pure, sortable, and being used by upper middle-class kids by mid-90s, and undoubtably some of those deaths included fentalogues.

Heroin quadrupled production in 2000s.
Someone used it...

@headdock

@headdock @Nashkitty66 @Canada_NV @hope411adcock @Chronic_FLKeys @bluelilly40 @Deeenst @ThomasKlineMD @StopBadDocs @HR4peopleinpain @chattyknana @maryann19711 @SpicyPurritos @Vlynx5 @SweetDeals16 @secondchances09 @Royalacresrod @Sarahkirk40 @soofriends @DebM01279692 @onnaroll66 @EbCummings1 @russell90367011 @CContrarus @eullrich11 @aander1987 @life_is_art___ @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall @twebber02 ...and it's clear from DEA pleading with Congress about fentalogue precursor regulations in 2007 it was a problem.

Couple that with exaggerated climb in 2000s prescribing, factoring OUT parallel quadrupling of major skeletal surgery increases, cancer survival advances...

Read 12 tweets

'fatbiker on a trike

@urbanfatbiker

27 Mar

Just what the f**&ing hell.

Power went out, direct strike on our pole. Worse, it must have hit one of our off-grid lites too!

So it also took out my inverter battery back-up. Blew the outputs. Scrapped it.

We have a genny and a gallon of gas.

Gonna be a long day.
🥺

I see our strike arrestor blown open, but utility says our outage is part of an ongoing incident.

Means they fix it, then we call back left behind. That's a few hours lost.

Then, damn system has the 'not A' address tagged to my number. But they have power.
Another delay.

Rescued the incubator it's on genny.

Wife wants grits.
I want heat.
And we have enough wattage for one or the other.

So I told her to buck up and have a bowl of cereal.

Or unplug the incubator???

Read 9 tweets

'fatbiker on a trike

@urbanfatbiker

19 Feb

"When he came to, he was on the floor. He had rolled out of the wheelchair and hit his head. A gaggle of worried-looking medical staff stood over him. They asked if he was on drugs."

In most ER, he would have already been hit with two doses of NARCAN.

nytimes.com/2018/07/24/mag…

#alphagal allergy syndrome breaks all rules, stands as example of how much we don't know. This guy got lucky. I have YET to meet medpro that knows this, except for my allergist.

Had I not studied myself and searched for answers, my PCP would have found them thru MY anaphylaxis.

Would it have been flu shot I refused? (2 of 4 have mammal component)..

Maybe the acid blocker I refused, in a gel-cap?

Would I have passed out during colon prep for procedure I refused?

How long before first 'incident' gets me narcanned? Hell I'm probably allergic to it too.

Read 19 tweets

'fatbiker on a trike

@urbanfatbiker

1 Sep 20

@DEEGILES0410

@DEEGILES0410 "total resolution relating to the marketing of Suboxone is more than $2 billion — the largest-ever resolution in a case brought by the Department of Justice involving an opioid drug."

Suboxone, the newest and most effective gateway drug, 'Prison Heroin', easy to smuggle.

@DEEGILES0410

@DEEGILES0410 "Buprenorphine emergency department (ED) visits for nonmedical use of the drug have increased fivefold from 2005 to 2011 – up to more than 20,000 ED visits involving buprenorphine products for nonmedical purposes.."

Thanks to Indivior.

americanaddictioncenters.org/suboxone/get-h…

@DEEGILES0410

@DEEGILES0410 "Suboxone may also be becoming a preferred drug of abuse for individuals seeking an opioid-like high, and many may be choosing this drug over other opioids."

EXACTLY as Kolodny intended when he started pushing Suboxone in 2005.

Read 10 tweets

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