1/
Now that estimated VE for severe COVID is down to 70-80% from those false estimates of >95%, we are still left with cardinal questions:
1. Still biased?
2. What is the effect of V on all-cause hospitalization/death?
Now that estimated VE for severe COVID is down to 70-80% from those false estimates of >95%, we are still left with cardinal questions:
1. Still biased?
2. What is the effect of V on all-cause hospitalization/death?
https://twitter.com/prof_shahar/status/1371634311867211777
2/
Still biased?
What are the characteristics of unvaccinated elderly?
Are there shared causes of V status and health outcomes?
Are those unvaccinated elderly (~10%) exchangeable with their vaccinated counterparts (90%) on key health-related variables?
Still biased?
What are the characteristics of unvaccinated elderly?
Are there shared causes of V status and health outcomes?
Are those unvaccinated elderly (~10%) exchangeable with their vaccinated counterparts (90%) on key health-related variables?
3/
For example, is the proportion of frail elderly similar in those populations?
All these questions convey a single concept in epidemiology: Confounding bias.
Example: if frail elderly make up 20% of unvaccinated but only 10% of vaccinated, true VE is lower.
For example, is the proportion of frail elderly similar in those populations?
All these questions convey a single concept in epidemiology: Confounding bias.
Example: if frail elderly make up 20% of unvaccinated but only 10% of vaccinated, true VE is lower.
4/
Next.
Monitoring systems make it clear that
V--> severe side effects/death.
What is the effect of V on all-cause hospitalization/death?
People need to know. That’s the ultimate VE. We die only once
They have the data. They will not be able to hide it forever
@MLevitt_NP2013
Next.
Monitoring systems make it clear that
V--> severe side effects/death.
What is the effect of V on all-cause hospitalization/death?
People need to know. That’s the ultimate VE. We die only once
They have the data. They will not be able to hide it forever
@MLevitt_NP2013
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