Viral load up 250 fold for delta variants in the vaccinated.

Does anti-spike selective pressure drive escape variants?

papers.ssrn.com/sol3/papers.cf…
The good news is all patient outcomes were uneventful.

Curious to know the Ct values of natural immunity plus delta variant.

The argument for boosters is based on neutralizing antibodies which seem irrelevant in this study.
Paper uses the term Viral Load but doesn’t really have one.
This PCR kit doesn’t have an internal control. There is no delta-delta qPCR.
Just a Drosten like E-gene PCR compared to a standard curve.

They should have a human Ct signal to normalize for the NP swab for a load. Image
That an 8 Ct shift (250) so even without the internal control, it does line up with other papers that suggest more RNA from delta variants.

Need some Vero cell confirmation to know if this is more sgRNA or full length gRNA.

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More from @Kevin_McKernan

14 Aug
Viability PCR exists.
Why is it not being utilized in C19?

What is Viability PCR?
Aka Capsid Integrity PCR.

It’s a method for only amplifying RNA that is inside a viral capsid.

Seems important for C19 given all the concerns over PCR Vs infectiousness. Image
There are several techniques which achieve this. The use of intercalating dyes is perhaps the oldest.
These dyes bind to free floating DNA or RNA and cross link it under UV.
Cross linked DNA/RNA doesn’t amplify.

DNA/RNA protected by a capsid is left unaffected. Image
So why isn’t the testing industry all over this?
It’s well known that your infectious window is 7 days and you can be PCR posture for over 30 days.
5X more people are positive if you don’t do this.
Read 8 tweets
13 Aug
Brings a new meaning to the shot heard around the world.
“If you try to forcible vaccinate one of my marines, you better come armed”.

🎤 drop Image
Read 4 tweets
13 Aug
If the pandemic gives one unlimited CTRL-P on the money machine, what could one do to keep it going and increase their power over society?

Since woke favors emotion over results, nearly anything can be justified. ImageImage
One could easily lambast those who question C19 screening fidelity at the border as xenophobic and racist.

I personally celebrate more migrants filling the shoes of the stimmy check couch potatoes.

I’m not a border person.

But when I see these two headlines same day..
It’s seems those in power have these polarized pandemic clans under their perfect control.

Stoke the xenophobia/border folks with covid leaks while choking their freedom of movement in the same stroke.

And team panic will cheer the whole shitshow power grab on.
Read 4 tweets
7 Aug
Anyone want to guess what’s wrong with this paper?

It’s making the rounds as some reason to wear masks. academic.oup.com/cid/advance-ar…
Here is one hint.
They target the N gene which is the highest copy subgenomic RNA in the genome.
SgRNA isn’t infectious.

N numbers are tiny.
Read 13 tweets
7 Aug
How it started
How it’s Going
Catnip synthesizes a Terpenes known as nepetalactones.

advances.sciencemag.org/content/6/20/e…
Read 5 tweets
3 Aug
A non sterilizing vax that delivers neutropenia in 46% of the victims.

Administered mid pandemic.
What could possibly go wrong?

@GVDBossche Warner against this.

Thankfully most of the population has T-cells from natural infection, otherwise...

bmj.com/content/371/bm…
This paper would foreshadow the nightmare to come.

Imperfect spike only vaccine across 1/3rd -1/2th the population is like putting low dose antibiotics into half the water supply.

Darwin Award.
2015 paper mentioned by @BretWeinstein

journals.plos.org/plosbiology/ar…
Overlap this with current data on the overlap of nAbs to spike RBD and these authors called it.

journals.plos.org/plosone/articl…
Read 4 tweets

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