COVID-19: Pediatric Hospital Admissions

I'm really hoping that anyone who doesn’t believe COVID-19 can be dangerous to children has seen what is going on in the USA now that schools have reopened with many jurisdictions are no longer requiring masks. 🧵1/
The USA continues to see spiking COVID-19 pediatric admissions to hospitals, now at 300 new children being admitted to hospitals each day and over 48,000 child admissions in the last year ( covid.cdc.gov/covid-data-tra… ). 2/ Image
Mississippi had almost 6,000 students test positive for COVID-19 in the last 2 weeks and 4500 cases at 803 schools in the last week alone which resulted in more than 20,000 students being quarantined last week ( mississippifreepress.org/14927/mississi… ). 3/
Just a week into grade 8, Mkayla Robinson died of COVID-19 only hours after testing positive. "The Children’s of Mississippi, the state’s only pediatric hospital, is currently full of children sick with COVID-19, including several on ventilators for life support." 4/
In the US there are around 27,500 staff pediatric beds and 5,400 pediatric ICU (PICU) beds ( ). Pediatric hospitals usually operate around 80% capacity with significant variation during the week and seasons. 5/
Since mask recommendations were lifted in many places, other viruses have an easier time spreading as well, RSV is already surging, well before the normal fall/winter appearance. 6/
There are additional RSV infected children in hospital now, on top of all the new COVID-19 patients they are dealing with. 7/
Pediatric beds cannot be easily staffed by adult-trained providers because children are not little adults, their normal vital signs are different and they have different fluid and medication requirements. Children get different diseases and complications. 8/
According to CDC data, from April to late July 2021 this year, children were being hospitalized at a rate of around 1% of infections. Of those children hospitalized, around a third (33%) got sick enough to require PICU care. 9/
With Delta, there are concerns it is making children even sicker which seems to have been confirmed in Canada where pediatric hospitalizations of children age 0-9 in Ontario are 2.7x higher with Delta compared to earlier strains ( ). 10/
Predictions for how Delta might spread in schools found that without mitigation 90% of elementary students will be infected by the end of the first semester, 80% within 2 months of schools opening, and the majority of cases within the first 30 days ( covsim.hosted-wordpress.oit.ncsu.edu/school-level-m… ).11/
They estimate that universal masking can reduce student infections up to 78% and biweekly testing along with masking reduces infections by another 50%. 12/
With 50 million school-aged children in the USA, and around 4 million who have already been infected with COVID-19, 8 million older children have been vaccinated. 13/
With asymptomatic infections they estimate another 8 million children were infected and have partial protection, that leaves 34 million susceptible school children. Note, the USA has almost as many susceptible school children as the entire population of Canada. 14/
If schools do not implement masking policies and 50% of the susceptible children are infected within the 30 days following the first two weeks of school that means an average of 570,000 children would be infected per day. 15/
If 1% of those are hospitalized, pediatric hospitals would need to care for 5700 new COVID admissions each day. But children don't usually stay just 1 day. 16/
The early variant in 2020 had an admission of 2.5 days on average which means 14,000 general pediatric beds and 4,300 PICU beds would be needed just for COVID patients. 17/
Reports from the field suggest this may be longer for Delta, and if the average stay increases to 4 days, that would increase to 23,000 general pediatric beds and 6,800 PICU beds which would overwhelm the pediatric capacities at hospitals. 18/
That doesn't even take into account beds required for all other reasons, including RSV outbreaks. Even if only 1% of children need hospitalization, a giant surge of pediatric cases needs to be prevented. 19/
This can be accomplished with universal mask wearing and improved ventilation and filtering in schools, regular rapid testing, and vaccinating those who are eligible. 20/

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More from @jeffgilchrist

8 Sep
COVID-19: UK decision not to universally vaccinate children 12-15

The UK's Joint Committee on Vaccination Immunisation (JCVI) recently announced they did not support universal vaccination of 12-15 year olds at this time ( gov.uk/government/new… ). 🧵1/
How did they come to a different conclusion than all the other countries who are already offering vaccines to those 12+ despite actually admitting that the benefits from the vaccine for 12-15 are "marginally greater than the potential known harms"? 2/
As usual, you need to look at the fine print and context they were using. First, they seemed to be using ICU treatment as their baseline and noted that only 2 healthy children per million need ICU care which was too small of a benefit ( washingtontimes.com/news/2021/sep/… ). 3/
Read 34 tweets
7 Sep
COVID-19: Immune antibodies vs T cells in protection

A very interesting study looked at which parts of the immune system are most important for clearing infections from the body ( science.org/doi/10.1126/sc… ). 🧵1/
The immune system has innate and adaptive immune responses ( ncbi.nlm.nih.gov/books/NBK26846/ ). The adaptive immune system remembers previous encounters with specific pathogens and destroys them when exposed again but is slow to develop on a first/primary exposure to a new pathogen. 2/
Specific clones of B and T cells have to become activated and could take a week or more before the immune responses are effective (this is why you are considered fully vaccinated 14 days after you get your dose). 3/
Read 8 tweets
21 Aug
COVID-19: Understanding efficacy when majority of hospitalized are vaccinated

I keep seeing more and more people confused about the raw # of reported COVID-19 cases or hospitalizations of vaccinated people. 🧵1/
The conclusion that some people are drawing is that this must mean the vaccines don't work. Except that they do, and work very well. The problem is with understanding the math, context, and something called Simpson's paradox which I will explain below. 2/
How can the efficacy of the vaccine vs. severe disease be strong when 60% of hospitalized in Israel are vaccinated for example? Jeffrey Morris put together an excellent article explaining all of this, which I will summarize ( covid-datascience.com/post/israeli-d… ). 3/
Read 28 tweets
20 Aug
COVID-19: Ventilation and filtration in Ontario schools

The Ontario government previously announced that they would be adding HEPA filters to classrooms that did not have mechanical ventilation. They released memo B14 ( efis.fma.csc.gov.on.ca/faab/Memos/B20… ) to explain:
🧵1/
- Updated ventilation best practice guidance
- Details of the investment in and approach to allocating standalone HEPA filter units
- Introduction of a standardized school ventilation report.
2/
School boards are required to ensure ventilation systems in all schools are inspected and in good working order prior to the start of the school year, and continue inspection and maintenance throughout the year. 3/
Read 18 tweets

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