mRNA injected into deltoid cells lasts about 72 hours and do not travel to distant sites in the body.
I get asked about this all of the time, so I went to find the primary science on this.
A couple of quick tweets
1/
I get asked about this all of the time, so I went to find the primary science on this.
A couple of quick tweets
1/
The first paper I can find on this was in @ScienceMagazine in 1990 and showed the half-life of RNA in muscle cells to be less than 24 hours- RNA encoding the luciferase protein was injected into mouse quads and luciferase was undetectable at 60 hours. pubmed.ncbi.nlm.nih.gov/1690918/
2/
2/
In 2007, a study agreed:
Luciferase-encoding mRNA injected into human ear dermis peaked transcription at 17h and was undetectable at 3 days (panel d).
They also looked for luciferase expression at distal sites in the ear and saw none (panel e).
pubmed.ncbi.nlm.nih.gov/17476302/
3/
Luciferase-encoding mRNA injected into human ear dermis peaked transcription at 17h and was undetectable at 3 days (panel d).
They also looked for luciferase expression at distal sites in the ear and saw none (panel e).
pubmed.ncbi.nlm.nih.gov/17476302/
3/
So when people ask you how long mRNA lasts in the body, you can now confidently tell them, having seen some of the primary literature.
Others know this area much better than me, and if there are better studies, I am all ears.
fin/
Others know this area much better than me, and if there are better studies, I am all ears.
fin/
Because @laxswamy:
Luciferase is a reporter protein that lights up, making it easy for scientists to detect expression in experiments.
It has nothing to do with Beelzebub; it just has an unfortunate name. It was discovered in 1887 by Raphael Dubois.
Luciferase is a reporter protein that lights up, making it easy for scientists to detect expression in experiments.
It has nothing to do with Beelzebub; it just has an unfortunate name. It was discovered in 1887 by Raphael Dubois.
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