"SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma" pnas.org/content/118/36… 
"The plasma fully neutralized the virus for seven passages, but, after 45 d, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough"
"At day 73, an E484K substitution in the receptor-binding domain (RBD) occurred, followed, at day 80, by an insertion in the NTD N5 loop containing a new glycan sequon, which generated a variant completely resistant to plasma neutralization."
Finally published @PNASNews by R. Rappuoli et al., including key Glycobiology structural issues (@RommieAmaro @LCasalino88)
Remember: this is what will happen (and what it is happening) if we will not vaccinate the full World, especially HIV+ patients, malnutrition-induced immuno-suppressed people etc. Their immune system will "work" in a way to (maybe) trigger the mutations described in this work.
Still curious to see what will happen to the RBD-based vaccines compared to the full Spike-based ones (mRNA, adenoviral etc).
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