I have included more references to the thread that many people provided. Thank you. Fixed a few links and tried to clarify a few points people were confused over.
That was written at 1:00AM and I didn't find the Edit button until an hour ago:)
Someone forwarded me a lazy take down on Ivermectin (Not from a PCR expert).
S/He clearly read the Abstract of this small 24 person study which does mislead the average reader into thinking you can't obtain viral inhibition with human doses of IVM.
And while the study didn't find significant differences in the patients that were called positive (they nearly all were), it did see a shift in Viral loads on IVM (orange). Thats a log scale on Y.
So, why does the article tone this observation down? The abstract and conclusion bury this? Read it and decide for yourself but be certain to read the COI section.
Let's look at another slightly larger study in the same Journal.
In this case the authors have internal controls in their PCR.
And they understand p450 genetics enough to know that you shouldn't just measure the oral dose given, but instead measure the plasma level of the drug as some patients clear the drug quickly.
When these variables are controlled for you can see a reduction in viral load. This is a very important metric for the pandemic. If you want to dial down the scariant parade, you need to slow the polymerase or increase its fildelity. Vax programs that don't change viral load...
Invite more viral evolution.
But there is more. If you are a PCR geek that has any experience making reversible terminators you know that PCR signal is going to over estimate infectious viral load particularly when Ivermectin has many modes of action. So, one should confirm.
What is the impact of Ivermectin not just on qPCR signals of the viral RNA but on viability or culturability of the virus? Recall, Not all RNA is full length and when you stall polymerases, your qPCR signal and culture signal can diverge.
I can imagine if you start this study with late treatment, it will be too late to see the difference as once the virus has gone exponential, the drug may not be able to stop it. Apply it early and you are far more likely to see the the polymerae stall.
This review from Trevor Bedford confirms this.
Spike evolution is off the charts.
He is obfuscating the truth by calling it “partial immunity”.
Just say it!
Spike only Vax w/ same CT is Dumb.
Good to see him visualize a world without lockdown.
This charts lay out the Ks/Ka evaluation mentioned above.
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The low wattage take that any attention given to GOF steals attention from ‘my pet thesis’, is two logical fallacies in one.
False dichotomy and a zero sum fallacy.
It is possible to be concerned about both GOF and lockdown tyranny at the same time.
Like chewing gum and walking.
There are usually 2 reasons such nonsense gets blathered about.
1)someone doesn’t want you to look at GOF.
2)marketing of substacks requires one differentiate from what’s currently capturing attention and appear divergent.
The reasons given NOT to look at GOF are rooted in denialism and molecular biology fairy tales.
‘RNA viruses can’t spread because <insert pseudo profound bullshit like quasi species swarm>’
When you show them evidence of measles and influenza having a higher mutation rate…
The latest scoobie snack is that RNA viruses mutate too quickly to ever spread… therefore GOF is all kabuki theatre.
This is clearly refuted by the sequencing data but let’s assume the argument stands…
Are these folks unaware of synthetic genomic projects making DNA viruses?
Epstein-Barr is a dsDNA herpes virus in 90% of the population. Clearly it can spread and it’s only 172kb.
Well under the size of the mycoplasma genome synthesized in 2008.
These don’t have the mutation rate of RNA and clearly reached 90% of the population.
They also can integrate and reactivate at a later date.
They cause mono so they are clearly ‘risk additive’
Would you trust Hotez or Daszak to be messing with these?
Posting again to remind folks that spike protein can drive mitophagy.
Now that we know the modRNAs are prone to frameshifting and there is a Mito peptide after the Pfizer stop codons, it wouldn’t surprise me if vaxxed patients have lower extracellular Mito.