Wow. The differences between pediatric Covid cases by region is stunning!!! #RealTimeCOVID19 Image
Well, this certainly got some attention. FWIW I was sharing a slide from a webinar I was attending, and I literally 'wow'ed when I saw it.

I live in NJ and am aware that schools haven't started here while they have in the south. I'm sure that's part of the explanation. 2/
Though the regions on this graph aren't defined, we know that the overall incidence of Covid between states is very imbalanced, even as it picks up across the US. The high incidence in the south and some western states is another factor here. 3/
Though the rates have been lower overall in the northeast, I don't think we're out of the woods by any stretch. It remains to be seen what happens when classrooms are filled with kids, masked or not, with the Delta variant dominating. It's an unknown. 4/
Vaccines for kids <12 are months away. IMO the best we can do now is vaccinate as many people as eligible, improve ventilation where we can, and universally mask in schools. 5/
I have a vaccinated 13 YO and a yet-to-be vaccinated 9 YO. While I know that the majority of cases of Covid in kids are not severe, I still worry for the younger one.

Here's hoping that we fare well as we travel in this unknown that is fall 2021. Be well, everyone. 6/

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More from @JGPharmD

1 Sep
A friend of mine with MS who received rituximab took a 3rd vaccine dose/booster at my urging three weeks ago just had an anti-spike IgG checked that was undetectable. Yes, antibodies aren’t the only part of the immune response, but I am going to use this as an example. 1/
He is a good example of a patient for whom casirivimab-imdevimab is useful for as post-exposure prophylaxis idsociety.org/practice-guide… 2/
The trial that showed benefit to cas-imdev prophylaxis showed a significant benefit in preventing symptomatic Covid-19. The patients who did develop symptoms also recovered more quickly, just as vaccinated patients generally have more mild disease. 3/ ImageImage
Read 6 tweets
15 Dec 20
Couple of notes on the Moderna VRBPAC FDA briefing document. A thread 1/
#VRBPAC #COVID19Vaccine
fda.gov/media/144434/d…
This is just beautiful. Note that the 2nd dose was given at day 28, and curves diverge around day 14. Early protection. 2/
They also give details about the ~2000 subjects who received only one dose. VE 14 days after the 1st dose was 92% (wide CI though) and 80.2% overall. 3/
Read 11 tweets

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