Does anyone besides me feel that the messaging over the last month in the US has basically served to terrify the vaccinated and make unvaccinated eligible adults doubt the effectiveness of the vaccines?
If I could message, I would start with history of infectious diseases, how the immune system works, how the vaccines are working well if you understand the immune system, and how (like Europe) we can get back to normal life with vax leaps.org/how-long-do-co…
Would also explain that asymptomatic transmission from vax'd with delta rare per contact tracing studies (CT values on PCR is a surrogate, contact tracing is how you determine transmission). Get source code here for Singapore data- we found 1 transmission covid.viz.sg/historic.html
from vax'd to vax'd if asymptomatic. 1 in huge case cluster analysis. Putting emphasis on masks over vaccination is a huge mistake for a country to do given the history of infectious diseases and how only immunity can get you through (preferably through vax). Masks ok; vax great
Also, don't believe CDC thinks there is significant spread from asymptomatic vaccinated people because they are not recommending routine testing of asymptomatic vax'd people (like they recommended testing of asymptomatic before vax) except after exposure; clearer messages please
I am mildly amused that I have been tweeting since April 2020 & have never received this many likes to a post around current US messaging terrifying the vaccinated and making unvax'd think vaccines don't work. Makes me wonder if we can change the message!
>10K likes: I write articles about immunity & get a few polite likes but it resonated with vax'd that being scared is opposite message to deliver about how well vax works, resonated with unvax'd that doubts intensified over past month. Immunity ONLY way to get through pandemic
• • •
Missing some Tweet in this thread? You can try to
force a refresh
This is likely study (just got released) pushing booster conversation in US for >60 (of note, booster discussion most relevant to places with high circulating virus due to low vax rates, not urgent in EU now). Data from Israel -not an RCT- nejm.org/doi/full/10.10…
but decision made in Israel to boost those >60 whose 2nd shot >5 months ago on June 30. This is data from July 30-August 31, 2021, from Israeli Ministry of Health database comparing those who had 3rd shot >=12 days before to those who had not. No matching on co-morbidities etc.
>= 12 days after booster, rate of confirmed infection lower (factor 11.3) in booster group than in nonbooster group as was rate of severe illness (factor of 19.5) . Better protection later on. Likely to push US to boost >60 while cases will circulating with our low vax rate
Don't have time to analyze this now but publicly-available documents that the FDA will review for their decision on boosters on Friday are now available here if you want to take a look fda.gov/media/152176/d…
FDA seems unconvinced so far but we need to go through it bit-by-bit and make a clean decision by Friday so will analyze the studies for you later today endpts.com/as-booster-sho…
However, this India study showing declining antibodies after vaccination is not really showing anything but how the immune system works. Antibodies wane to avoid your blood becoming the consistency of a milkshake but memory cells make more reuters.com/world/india/in…
Discussing balance, nuance, risk factors for COVID (before vax or even after vax, including heart disease, obesity, etc.) is important. Episode with @DrTomRifai & @DrDavidKatz about balance, collateral damage of pandemic (ok to say that word) and 1918 pandemic
For instance, even fetal stress in 1918 due to health, lower attainment of adulthood income, and occupational fulfillment led to shorter lifespans. Similar to discussions of long-acting impacts of our prolonged school closures in US last year (balance) read.dukeupress.edu/demography/art…
Cohorts born during 1918 pandemic and in its aftermath exposed to stress, which leads to inflammation which has long-term health effects (on cancer, cardiovascular disease, etc.) ajph.aphapublications.org/doi/10.2105/AJ…
A lot on boosters & immunity (the higher the better; obviously in a surge, immunity goes higher but vaccination rates up too) this week with a summary on @MdMashup mashupmd.com/weekly-expert-…
Nice paper this morning from Lancet on "Considerations on boosting COVID-19 vaccine immune responses". "The vaccines that are currently available are safe, effective, and save lives. The limited supply of these vaccines will save the most lives if made .. thelancet.com/pb-assets/Lanc…
available to those who are at appreciable risk of serious disease and have not yet received any vaccine. Even if some gain can ultimately be obtained from boosting, it will not outweigh the benefits of providing initial protection to the unvaccinated" [ and tamping down variants]
NOVAVAX vaccine: Want to do a thread on this more traditional vaccine as it involves a protein (spike protein) + an adjuvant instead of genetic material for you to code for spike protein. Remember, we have >9 vaccine candidates worldwide
6 of the vaccines involve the spike protein (5 have you produce the spike protein from genetic code; 1 - Novavax- is the spike protein + adjuvant) and 3 are inactivated whole virions. Spike protein attaches virus to cell
Here are the 6 that involve the spike protein including Novavax so let's explain the latter next and data to date
Realistic article by @DLeonhardt walking us through risks to the vaccinated of the delta variant. "In Britain, many people have become comfortable with current Covid risks. Vaccines make serious illness rare in adults, and risks to young children are low" nytimes.com/2021/09/07/bri…
"There's a feeling we can finally breathe, get back to what we have lost" in UK "Many Americans feel differently. Our level of Covid anxiety is higher, especially in communities that lean to the left politically. ..But at least one part of the American anxiety does seem to have
"become disconnected from the facts in recent weeks: the effectiveness of the vaccines...". Despite recent poll showing many vax'd Americans still think they can get very sick, "In reality, the risks of getting any version of the virus remain small for the vaccinated"