Some more thoughts prompted by this article - the notion of an 'end' to the pandemic is itself faulty in my opinion. But that emphatically does *not* mean interventions forever. It means that the transition to endemic disease can and should be managed 1/?
The reason 'end' is dangerous is that it suggests a date when everything changes overnight and we return to 'normal'. That takes no account of variants, waning immunity or the fact that most of the world is struggling to access vaccines, among many other things 2/?
However in vaccinated places it is true things are *much* better than they easily could be, but that doesn't mean the pandemic is 'over'. This is Oregon and Idaho *now*. 3/? nytimes.com/2021/09/06/us/…
While here in MA, despite a large well publicized outbreak in July cases have not skyrocketed. The deaths column has remained mercifully low. We can expect both to increase at least somewhat as the fall rolls around, but this shows that Delta spikes are not inevitable 4/?
Is the pandemic 'over' in MA? Of course not! There will likely be many further bumps in the road, not least because summers are quiet virus wise. That's why there are multiple interventions in place. They're not exactly intense though... 5/?
The urge to declare an 'end' is related to the wish for silver bullets I describe here also in the Post (never let it be said the paper only shows one viewpoint). But declaring an end is bizarre when you can look out the window and see it still going on 6/?washingtonpost.com/outlook/2021/0…
Fighting the virus is more like achieving sustained weight loss. We would all like there to be an easy way to do it, one simple trick. But years of research by people who know more about nutrition than I do have shown it is more complicated than that 7/?
Finally, none of this means the pandemic will be with us forever. It means that Delta is going to infect a lot of people, and the next few months will be hard. We can make them easier with vaccination and other interventions 8/?
(to be clear, the goal is to avoid uncontrolled Delta spikes which send vulnerable unvaccinated *and* those relatively few vaccinated folks who remain vulnerable, into hospitals in a surge. Some places are already struggling with that) 9/?
In due course, almost everyone will have immunity of some sort, and so the virus will never have again such unfettered access to so many hosts. Whether that will be the 'end' depends on the epi and clinical characteristics of breakthroughs and reinfections 10/?
Eventually the virus will become something of interest to specialists, and the public will be able to move on. It will cause disease and death, but not in the numbers we see now. Indeed, the article prompting this thread describes such a situation. But we're not there now 11/?
Now we are seeing record hospitalizations, even while vaccines are available that could prevent them. Once again, a future epidemiologists saw coming is playing out before our eyes.

It's an incredibly tone-deaf time to be talking about 'endings' 12/end

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More from @BillHanage

15 Sep
When I see statements like this, especially now, I wonder what people mean by "the overwhelming of [healthcare]"

We shouldn't talk about healthcare being overwhelmed, we should talk about it being compromised or otherwise damaged, in a way that could have been avoided 1/?
Healthcare is compromised when elective surgeries are canceled, when screening is canceled. It is compromised when we run low on ICU nurses because they are needed in too many places or because they are sick with a virus 2/?
It is compromised when campaigns against scourges like malaria, TB or polio are damaged because of an uncontrolled pandemic 3/?
Read 5 tweets
3 Sep
I follow twitter less than you might think, but I have noticed a trend for people calling themselves "covid centrists". I find this difficult because it suggests a spectrum between extremes. I'm not a covid anythingist, I am just a scientist
This means I think about claims based on the evidence for them as I understand it. If you ask me what I think will happen if we take a particular action, I can tell you that.
That means I also need to admit when things don't go as I expected. For eg, while I expected (and publicly predicted) a dent in the rate of increase in the UK as the schools closed, before transmission resumed. But I was surprised by the scale of the drop. Now about that...
Read 8 tweets
3 Sep
Trying to write a couple talks for next week based on this new preprint from us on how we expect vaccines to perform against variants with enhanced transmissibility, some immune evasion, or both. A🧵may follow as I sort my thoughts out
medrxiv.org/content/10.110… 1/?
One important thing - it is always important to compare impacts of vaccination against the alternative, so we've estimated infections averted for a simple model, and varied stuff like time and pace of vaccine introduction and the point at which variants emerge 2/?
I called it a simple model, but it has quite a lot of compartments. The arrows are the possible ways people move from S (susceptible) through being I (infected) or V (vaxxed). Resistant (thanks to immunity from infection R) and various breakthroughs 3/?
Read 18 tweets
17 Aug
Nate seems to be doubling down on claiming my thread said something that it didn’t. I can accept a lot of misunderstanding but this is something more. This looks like deliberately mischaracterizing what I said for clicks. I am really disappointed 1/x
The point is that places with more immunity should have to work less hard to avoid/control delta surges. Australia has little immunity, due to a very successful early pandemic management approach and a much less successful vaccination program 2/x
In contrast FL and TX have a lot of immunity, due to both a lot of infections and a lot more vaccination. Yet hospitalizations are rocketing there because there is no will to enact *mild* interventions to prevent transmission of delta 3/x
Read 8 tweets
16 Aug
Delta is really transmissible, which is much worse than immune escape. On the other hand, there’s reasons for optimism from the likes of Australia and Vietnam that we can take action other than vaccination to stand on its way. Let me explain… 2/x
Here’s FL and TX, both with substantial prior infection and non trivial vaccination. Cases as high as they’ve ever been (or higher) and they’ve been darned high already and a lot of people have died already. This is down to Delta, and minimal local interventions to combat it 3/x
In contrast Australia. That steep climb reflects the threat of delta, but look at the absolute numbers and recall Australia has *never* had a significant outbreak, so this is small relative to FL and TX and with very little population immunity. It could easily be worse 4/x
Read 6 tweets
9 Aug
There has been a lot of noise about the proportion of COVID cases, hospitalizations and even deaths that occur among vaccinated people. This is misleading. In this working paper we show how getting vaxxed improves your chances using relative risk cdn1.sph.harvard.edu/wp-content/upl… 1/x
This is the formula relating relative risk of an outcome for unvaxxed vs vaxxed people to efficacy. It tells you how many more time likely an unvaxxed person is to die, be hospitalized etc, relative to a vaxxed person 2/x
Sorry for big table, but the headline finding is that unvaxxed persons were between 5 and 133 times *more likely to be hospitalized* and between 9 and 141 *more likely to die* in comparison with fully vaxxed 3/x
Read 8 tweets

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