2/ In states with a high incidence of the Delta variant, vaccine effectiveness in June/July 2021:
~80% vs *any* diagnosis of COVID
~85% vs hospitalization from COVID
4/ A single dose of the J&J vaccine works really well at preventing hospitalization (& death).
~80-85% protection against hospitalization is only slightly lower than what we're seeing with 2 doses of the mRNA vaccines (~85-90%) fda.gov/media/152241/d…
5/ 2nd dose of J&J vaccine given 56 days after 1st dose yielded:
100% protection vs severe COVID
75% protection vs symptomatic COVID worldwide
94% protection vs symptomatic COVID in the U.S.
**note: median follow up was only 36 days after 2nd dose**
6/ J&J COVID vaxx is an important tool for vaccinating people in the US & globally.
1 shot = great
2 shots = excellent
But we need to continue following vaccine effectiveness, esp vs hospitalization/death, over time (as with mRNA vaccines) to confirm no waning of protection.
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1/ How did Denmark get 95% of people 50+ fully vaccinated?
"citizens’ high and stable trust in their health authorities has been a crucial factor"
"lack of trust in authorities... is one of the primary reasons people refuse to get vaccinated"
2/ "transparent communication about all features of vaccines—including the negative ones—is key to sustain trust, even if in the short run it reduces vaccine acceptance" washingtonpost.com/politics/2021/…
3/ "trust between citizens and the authorities ideally runs both ways, as authorities need to trust that citizens can weather bad news and still make responsible decisions" washingtonpost.com/politics/2021/…
1/ The decision to not get vaccinated, from the perspective of the unvaccinated
by @davidlazer & colleagues osf.io/fazup/
Life constraints
Perception of benefit
Perception of risk
Uncertainty regarding the risks of vaxx
Lack of trust in institutions
Fear of needles
2/ About 2/3 of respondents had already gotten at least 1 dose of vaccine.
15% willing to get vaccinated.
But 18% won't get vaccinated.
3/ Among those not yet vaccinated, here are their reasons for not getting vaccinated:
#1, #2 They are worried about the risks of vaccination.
#3 Lack of trust in institutions (eg gov't, healthcare)
#4 Don't see much of an upside (ie don't think they're at risk for COVID)
2/ There is good evidence to back additional doses of COVID vaccine for:
- HIGHLY immunocompromised
- Elderly
AND
- Nursing home residents
- Single-dose J&J recipients
BUT NOT for the general public at this time.
3/ We need to be thinking about the endgame, otherwise, we could find ourselves in a situation like Israel, chasing our tail with booster after booster: