Keberkesanan Vaksin Pfizer & Moderna Melawan Delta
Dikalangan 5.6 Juta  Warga Emas 🇺🇸 >65 tahun
✅2.7 Juta Pfizer
✅2.9 Juta Modera
➡️148K Infeksi Breakthrough (2.6%)
➡️30K Masuk Hospital (20%)
➡️9.4K Masuk ICU (34%)

humetrix.com/powerpoint-vac… Image
✅Kadar Infeksi Breakthrough (IB) ➡️2.6%
✅Kadar masuk hospital IB ➡️20% (32% Mar-Dis 2020)
✅Kadar masuk ICU ➡️34% (32% Mar-Dis 2020)
✅Kadar mati➡️2.2% (12% Mar-Dis 2020) Image
✅Perlindungan dari masuk hospital ⬇️ dgn masa
✅Keberkesanan vaksin ⬇️ dimasa 5-6 bln > 3-4 bln lepas vaksinasi
✅Risiko Infeksi Breakthrough masuk hospital ⬆️ 2.5X ganda 6 bln lepas vaksinasi Image
⬇️ Perlindungan berlaku untuk kedua vaksin Pfizer dan Moderna Image
Lagi tua lagi ⬆️ risiko berlaku Infeksi Breakthrough dan masuk hospital Image
Infeksi covid terdahulu + vaksin memberi perlindungan yg baik ➡️ Imuniti Hybrid ImageImage

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More from @drmusanordin

16 Aug
Tahap neutralizing antibodi lepas vaksinasi menentukan perlindungan-correlate of protection
➡️Neutralisasi boleh menjangka perlidungan drp sesuatu jenis vaksin.
➡️Model yg bakal diguna pakai utk mengawal trajektori pandemik dgn strategi vaksinasi
nature.com/articles/s4159…
Amat besar jurang perbezaan titer antibodi (ab) antara vaksin mRNA & Sinovac.
Lepas 28 hari dos ke2
➡️Tahap ab PRNT50 mRNA 10X ganda
➡️Tahap ab PRNT90 mRNA 13X ganda
➡️Perbezaan 10-13X ganda tahap ab merupakan perbezaan yg besar didlm keberkesanan vaksin – Vaccine Efficacy (VE)
Keberkesanan vaksin (VE) ditentukan oleh antibodi & respon imun yg lain.
Universiti Hong Kong (HKU) menunjukkan vaksin mRNA lebih berkesan drp Sinovac kerana tahap ab yg 10X lebih tinggi.
Pengkaji HKU syorkan dos tambahan untuk penerima vaksin Sinovac
 
hongkongfp.com/2021/07/16/cov…
Read 6 tweets
13 Aug
Wanita yg hamil & dijangkiti covid:
⬆️Covid teruk
⬆️Masuk ICU
⬆️Bantuan pernafasan
⬆️3X Mati dibandingkan dgn wanita covid yg tidak hamil
⬆️Sebab komobiditi hamil spt kencing manis, darah tinggi.
⬆️Keguguran
⬆️Kelahiran mati
⬆️Kelahiran pramatang

rcog.org.uk/globalassets/d…
Vaksin Selamat
➡️2.4 juta wanita hamil terima pelbagai vaksin covid & selamat
➡️130K wanita terima vaksin mRNA & tiada kesan sampingan
➡️Ujian pra-klinikal tiada risiko kpd ibu atau kecacatan janin
➡️Kandungan Vaksin dah dinyah
➡️mRNA tak masuk nukleus

medrxiv.org/content/10.110…
Read 10 tweets
9 Aug
An oversimplification of the science
1. In first few days of illness viral loads (VL) r similar bet vaxxed & unvaxxed
2. NHS study only captured the early few days of symptomatic persons.
3. 90-97% mRNA and 70% AZ vaxxed are asymptomatic!
3. Though similar VL are they viable in vaxxed vs unvaxxed?
4. VL in vaxxed maybe rendered non-viable and/or less infectious. by neutralising antibodies
5. VL in unvaxxed are replication competent virus
6.    PCR cannot differentiate between them threadreaderapp.com/thread/1424780…
7. We need a replication assay
8. After few days the VL drops faster in vaxxed below the contagious level.
9. Vaxxed persons overcome infxn faster-period of infectiousness shorter
10. Play safe scenario-vaxxed & PCR positive should isolate during 1st wk of infxn
11. Get vaxxed!
Read 4 tweets
7 Aug
Transcript of the conversation in question.

facebook.com/ResetMalaysia.…

Minutes 57:00-57:50
Dr. Abu Hafiz:
Moderna telah pun diluluskan di USA dan banyak negara yang lain, tetapi seperti mana yang Dato' sebutkan, NPRA masih belum lagi meluluskan. (1)
Apa sebenarnya masalah kepada kita dalam menerima vaksin-vaksin yang telah diluluskan di dalam negara-negara maju? (2)
Dato' Dr. Musa Mohd Nordin:
Moderna telah diluluskan pada bulan 12 last year (US), 8 months ago. Kita luluskan dulu Pfizer, lepas tu Sinovac, lepas tu AZ. fda.gov/emergency-prep…
Read 4 tweets
6 Aug
DG MOH 1991-2001:
“many questions had been raised by the suspension of Parliament, adding that the rationale behind it was not clear to him”
“must ensure that all his decisions were made with professionalism rather than political considerations.
freemalaysiatoday.com/category/natio…
God gave him a golden opportunity to save 32 million people.
To save a whole nation in crisis and engulfed in a deadly pandemic.
Instead he chose to save one person.
An unprecedented dereliction of trust & responsibility.
Dishonouring a doctor’s oath Primum Non Nocere
Parlimen:
1. 90% vaccinated ie Herd Immunity

2. Positive rate 0.8% Very much less than WHO 5% threshold

Parlimen one of the safest place on earth after NZ!

Science: Parlimen boleh bersidang
Read 7 tweets
29 Jul
This is more fun than cows in condominium.
The parliament is convulsing in pandemonium.
The speaker is behaving like foetid meconium.
His spine needs fixing with rods of titanium.
Sidang Parlimen sudah dicuri
PM dan Speaker dah cabut lari
DiJepun kalau Raja diingkari
Kabinet semua wajib harakiri
This is truly a historical moment
Actually it’s such an embarrassment
Kesian! DSAI  & PH are locked in parliament
PM takut he take over government :)
Read 8 tweets

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